Procollagen Plus

Name: Procollagen Plus
SKU: ACTPRO
Price: 67.70 EUR
Availability: InStock

Active

National Code: 209499.4

330 g (30 servings)

Dietary supplement based on collagen, glucosamine, MSM, amino acids, plant extracts, vitamins and minerals, with sweetener that contributes to the formation of skin and bone collagen, the normal functioning of cartilage and connective tissue and the maintenance of bones in normal conditions.

Product Features

Contains fish

Gluten free

Lactose free

Product benefits

Skin

Bones and joints

Nutricosmetics

Nails

Product Features

Contains fish

Gluten free

Lactose free

Main assets ofProcollagen Plus

Peptan® (Collagen)

(Hydrolyzed Fish Collagen)

Peptan® is the leading brand of collagen peptides, collagen provides flexibility and cohesion in muscles and bones.

Aquamin™ (Calcium)

(Algae Lithothamnion calcareum)

Aquamin™ is a source of calcium, necessary for the maintenance of bones under normal conditions.

Magnesium

(Carbonate)

Contributes to the maintenance of bones under normal conditions.

Glucosamine

Glucosamine is a naturally occurring compound found in cartilage, the tough tissue that protects joints.

OptiMSM® (MSM)

(Methylsulfonylmethane)

Methylsulfonylmethane, MSM, is an organic form of sulfur that helps strengthen connective tissue.

Hyaluronic acid

Hyaluronic acid is found in the tissues of our skin and acts as a 'storehouse' for water molecules.

MenaQ7® (Vitamin K)

(Menaquinone-7)

MenaQ7® is a vitamin K2 and contributes to the maintenance of normal bones.

Vitamin D₃

(Cholecalciferol)

Contributes to the maintenance of bones under normal conditions and the functioning of muscles.

Peptan® (Collagen)

Collagen is a protein found in almost every part of the body, including skin, bones, joints, muscles, and tendons.
In fact, 30% of all proteins in the human body are made up of collagen.
The function of collagen is to provide flexibility and cohesion in the muscles, that is, it keeps them united and elastic. Unlike vitamins and minerals, it is not difficult to obtain collagen through food because collagen is found in indigestible areas such as skin, bones, genes, and bones. There are more than 20 types of collagen, however, the best known are type I, II and III.

Type I: It is the most abundant type and we find it in the skin.
Also in bones and tendons.
Among its main functions is to give elasticity and resistance, as well as it has a support function.
Type II: Found in joints and cartilage.
It is a flexible and strong tissue that covers the joints.
It provides resistance and helps to lubricate these tissues that are under constant pressure.
Type III: It is a larger molecule than the previous two and is closely related to type I. It is present in muscles, blood vessels, and the lining of the intestines.
We can also find it in the skin.
It is responsible for supporting the organs.

As a curiosity, type I and type III collagen have to be hydrolyzed.
This is because it is a very large molecule and our body is not able to digest it.
Hydrolyzed collagen is a type of collagen which has been processed and cut into small particles so that it can be easily absorbed.
Once ingested, this collagen is able to gather and recreate its original shape so that it fulfills its function.
Type II collagen, however, has to be native, meaning it works best if it’s unprocessed. Peptan® is the leading brand of collagen peptides (also known as hydrolyzed collagen) that has been shown in scientific studies to have multiple health benefits.
Peptan® is a collagen from fish. Peptan® contains 18 amino acids, the building blocks of our tissues and the main building block of proteins.
Glycine, proline, and hydroxyproline account for about 50% of Peptan’s® total amino acid content (the concentration of glycine and proline in Peptan® is 10 to 20 times higher than in other proteins).
As a result, Peptan® possesses multifunctional properties that cannot be found in other protein sources. Peptan’s® range of collagen peptides are safe, bioactive and developed using an optimised hydrolysation process, making collagen peptides highly bioavailable and providing specific benefits in key connective tissues of the human body. To ensure excellent bioactivity, it is critical that collagen reaches the target tissues as efficiently as possible and is highly bioavailable. Peptan® is easily digested and absorbed very well. Peptides reach the bloodstream within an hour of ingestion.
From the blood, peptides (containing hydroxyproline, a unique amino acid) are transported to target tissues, e.g. skin, bones and cartilage, where they send a signal to local cells and help the cells improve their function.
This functional adaptation is the basis of the health benefit experienced by the consumer.
This means high bioavailability.

Shigemura Y, et al. 2009. Effect of prolyl-hydroxyproline (Pro-Hyp), a food-derived collagen peptide in human blood, on growth of fibroblasts from mouse skin. Journal of Agricultural and Food Chemistry 57(2), 444-449

Inoue N, Sugihara F, Wang X. Ingestion of bioactive collagen hydrolysates enhance facial skin moisture and elasticity and reduce facial ageing signs in a randomised double-blind placebo-controlled clinical study. J Sci Food Agric. 2016 Sep;96(12):4077-81. doi: 10.1002/jsfa.7606. Epub 2016 Feb 10. PMID: 26840887.

Asserin J, Lati E, Shioya T, Prawitt J. The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. J Cosmet Dermatol. 2015 Dec;14(4):291-301. doi: 10.1111/jocd.12174. Epub 2015 Sep 12. PMID: 26362110.

Matsumoto, Hitoshi & Ohara, H. & Itoh, K. & Nakamura, Y. & Takahashi, S.. (2006). Clinical effects of fish type I collagen hydrolysate on skin properties. ITE Letters. 7. 386-390.

Sibilla S, Godfrey M, Brewer S, Budh-Raja A, Genovese L. An overview of the beneficial effects of hydrolysed collagen as a nutraceutical on skin properties: Scientific background and clinical studies. The Open Nutraceuticals Journal. 2015;8:29-42.

Proksch E, Segger D, Degwert J, Schunck M, Zague V, Oesser S. Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study. Skin Pharmacol Physiol. 2014;27(1):47-55.

Asserin J, Lati E, Shioya T and Prawitt J, 2015. The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. Journal of Cosmetic Dermatology, 14: 291–301. doi: 10.1111/jocd.12174

Ohara H, Ichikawa S, Matsumoto H, Akiyama M, Fujimoto N, Kobayashi T, Tajima S, 2010. Collagen-derived dipeptide, proline-hydroxyproline, stimulates cell proliferation and hyaluronic acid synthesis in cultured human dermal fibroblasts. J Dermatol 374: 330-338

Matsuda N, Koyama Y, Hosaka Y, Ueda H, Watanabe T, Araya S, Irie S, Takehana K, 2006. Effects of ingestion of collagen peptide on collagen fibrils and glycosaminoglycans in the dermis. J Nutr Sci Vitaminol 52: 211-215

Okawa T, Yamaguchi Y, Takada S, Sakai Y, Numata N, Nakamura F, Nagashima Y, Ikezawa Z, Aihara M. Oral administration of collagen tripeptide improves dryness and pruritus in the acetone-induced dry skin model. J Dermatol Sci. 2012 May;66(2):136-43. doi: 10.1016/j.jdermsci.2012.02.004. Epub 2012 Feb 19. PMID: 22410290.

Ichikawa S, Morifuji M, Ohara H, Matsumoto H, Takeuchi Y, Sato K, 2010. Hydroxyproline-containing dipeptides and tripeptides quantified at high concentration in human blood after oral administration of gelatine hydrolysate. Inter J Food Sci Nutr 61 (1): 52-60

Jiang J.X. et al., 2014, Collagen peptides improve knee osteoarthritis in elderly women: A 6-month randomized, double-blind, placebo controlled study. Agro FOOD Industry Hi Tech, 25:19-23

Guillerminet F, Beaupied H, Fabien-Soulé V, Tomé D, Benhamou CL, Roux C, Blais A. Hydrolyzed collagen improves bone metabolism and biomechanical parameters in ovariectomized mice: an in vitro and in vivo study. Bone. 2010 Mar;46(3):827-34. doi: 10.1016/j.bone.2009.10.035. Epub 2009 Nov 4. PMID: 19895915.

Dar, Q. et al., 2017. Daily oral consumption of hydrolyzed type 1 collagen is chondroprotective and anti-inflammatory in murine posttraumatic osteoarthritis. PLoS ONE 12(4):e0174705

Soniwala, S. et al., 2018, Oral Hydrolyzed Type 2 Collagen Protects Against the OA of Obesity and Mitigates Obese Gut Microbiome Dysbiosis. Poster presentation at ORS 2018 and OARSI 2018

Clifford T, Ventress M, Allerton DM, Stansfield S, Tang JCY, Fraser WD, Vanhoecke B, Prawitt J, Stevenson E. The effects of collagen peptides on muscle damage, inflammation and bone turnover following exercise: a randomized, controlled trial. Amino Acids. 2019 Apr;51(4):691-704. doi: 10.1007/s00726-019-02706-5. Epub 2019 Feb 19. PMID: 30783776.

Aquamin™ (Calcium)

Aquamin™ is a natural multimineral of marine origin, which is obtained from the cytoskeleton of the red algae Lithothamnion spp, from which calcium is mainly obtained.
Procollagen Plus contains 2500 mg of Aquamin™, of which 800 mg are calcium.
Lithothamnium calcareum belongs to the group of marine red algae of the Coralineceae family that develop at great depths in the presence of light.
During its growth stage, the algae absorbs nutrients and minerals from the sea by osmosis.
Throughout the algae’s life, minerals from seawater accumulate and are stored as carbonate salts in the plant cell wall.
Algae contain 10 to 15 times more trace elements than land plants.
The raw material, calcium, is obtained from the calcareous skeleton.
Calcium is found in calcium carbonate format. Aquamin™ is sustainably harvested in the crystal clear waters off Iceland’s north coast.
Calcium and magnesium account for one-third and more than 2%, respectively, of the more than 70 component minerals of Aquamin’s™ total dry mass. Aquamin™ has an intricate and unique three-dimensional structure shaped by the cell wall of Lithothamnion sp. Aquamin™ has been shown to have superior bioavailability than other commonly available sources of calcium and has beneficial effects on bones, inflammation, specifically osteoarthritic conditions, digestive health, and cardiovascular health. One of the characteristics of this calcium is its high bioavailability, since at high pH it is soluble. Calcium (Ca) is the most abundant mineral in the human body.
More than 99% of the calcium present in the human body is stored in bones and teeth; The remaining 1% is found in the blood, muscles, and fluids between cells. Among the sources, calcium is mostly found in dairy products.
Other sources of calcium are almonds, brewer’s yeast, broccoli, cabbage, dried figs, kelp, dark leafy vegetables, hazelnuts, oysters, sardines, and canned salmon.

Among the functions, calcium contributes:

to the maintenance of bones in normal conditions.
to the maintenance of teeth in normal conditions.
to normal blood clotting.
to normal energy metabolism.
to the normal functioning of the muscles.
to the normal functioning of neurotransmission.
to the normal functioning of digestive enzymes.
to the process of cell division and cell differentiation.

Frestedt JL, Walsh M, Kuskowski MA, Zenk JL. A natural mineral supplement provides relief from knee osteoarthritis symptoms: a randomized controlled pilot trial. Nutr J. 2008 Feb 17;7:9. doi: 10.1186/1475-2891-7-9. PMID: 18279523; PMCID: PMC2265739. A natural mineral supplement provides relief from knee osteoarthritis symptoms: a randomized controlled pilot trial – PubMed (nih.gov)

Frestedt JL, Kuskowski MA, Zenk JL. A natural seaweed derived mineral supplement (Aquamin F) for knee osteoarthritis: a randomised, placebo controlled pilot study. Nutr J. 2009 Feb 2;8:7. doi: 10.1186/1475-2891-8-7. PMID: 19187557; PMCID: PMC2642861. A natural seaweed derived mineral supplement (Aquamin F) for knee osteoarthritis: a randomised, placebo controlled pilot study – PubMed (nih.gov)

Murphy CT, Martin C, Doolan AM et al., 2014, The marine-derived, multi-mineral formula AquaPT reduces TNF-a levels in osteoarthritis patients. J Nutr Health & Food Sci. 2014 2(3):1-3. (PDF) The Marine‐derived, Multi‐mineral formula, AquaPT Reduces TNF- Levels in Osteoarthritis Patients (researchgate.net)

Ryan S, O’Gorman DM, Nolan YM. Evidence that the marine-derived multi-mineral Aquamin has anti-inflammatory effects on cortical glial-enriched cultures. Phytother Res. 2011 May;25(5):765-7. doi: 10.1002/ptr.3309. Epub 2010 Oct 26. PMID: 21520469.Evidence that the marine-derived multi-mineral Aquamin has anti-inflammatory effects on cortical glial-enriched cultures – PubMed (nih.gov)

O’Gorman DM, O’Carroll C, Carmody RJ. Evidence that marine-derived, multi-mineral, Aquamin inhibits the NF-κB signaling pathway in vitro. Phytother Res. 2012 Apr;26(4):630-2. doi: 10.1002/ptr.3601. Epub 2011 Oct 28. PMID: 22034197. Evidence that marine-derived, multi-mineral, Aquamin inhibits the NF-κB signaling pathway in vitro – PubMed (nih.gov)

O’Gorman DM, Tierney CM, Brennan O, O’Brien FJ. The marine-derived, multi-mineral formula, Aquamin, enhances mineralisation of osteoblast cells in vitro. Phytother Res. 2012 Mar;26(3):375-80. doi: 10.1002/ptr.3561. Epub 2011 Jul 12. PMID: 21751268. The marine-derived, multi-mineral formula, Aquamin, enhances mineralisation of osteoblast cells in vitro – PubMed (nih.gov)

Widaa A, Brennan O, O’Gorman DM, O’Brien FJ. The osteogenic potential of the marine-derived multi-mineral formula aquamin is enhanced by the presence of vitamin D. Phytother Res. 2014 May;28(5):678-84. doi: 10.1002/ptr.5038. Epub 2013 Jul 19. PMID: 23873476. https://pubmed.ncbi.nlm.nih.gov/23873476/ The osteogenic potential of the marine-derived multi-mineral formula aquamin is enhanced by the presence of vitamin D – PubMed (nih.gov)

Brennan O, Stenson B, Widaa A, O Gorman DM, O Brien FJ. Incorporation of the natural marine multi-mineral dietary supplement Aquamin enhances osteogenesis and improves the mechanical properties of a collagen-based bone graft substitute. J Mech Behav Biomed Mater. 2015 Jul;47:114-123. doi: 10.1016/j.jmbbm.2015.03.015. Epub 2015 Apr 1. PMID: 25884141. Incorporation of the natural marine multi-mineral dietary supplement Aquamin enhances osteogenesis and improves the mechanical properties of a collagen-based bone graft substitute – PubMed (nih.gov)

Zenk JL, Frestedt JL, Kuskowski MA. Effect of Calcium Derived from Lithothamnion sp. on Markers of Calcium Metabolism in Premenopausal Women. J Med Food. 2018 Feb;21(2):154-158. doi: 10.1089/jmf.2017.0023. Epub 2017 Oct 12. PMID: 29023178. Effect of Calcium Derived from Lithothamnion sp. on Markers of Calcium Metabolism in Premenopausal Women – PubMed (nih.gov)

Slevin MM, Allsopp PJ, Magee PJ, Bonham MP, Naughton VR, Strain JJ, Duffy ME, Wallace JM, Mc Sorley EM. Supplementation with calcium and short-chain fructo-oligosaccharides affects markers of bone turnover but not bone mineral density in postmenopausal women. J Nutr. 2014 Mar;144(3):297-304. doi: 10.3945/jn.113.188144. Epub 2014 Jan 22. Erratum in: J Nutr. 2014 Jul;144(7):1125. PMID: 24453130. Supplementation with calcium and short-chain fructo-oligosaccharides affects markers of bone turnover but not bone mineral density in postmenopausal women – PubMed (nih.gov)

Barry DW, Hansen KC, van Pelt RE, Witten M, Wolfe P, Kohrt WM. Acute calcium ingestion attenuates exercise-induced disruption of calcium homeostasis. Med Sci Sports Exerc. 2011 Apr;43(4):617-23. doi: 10.1249/MSS.0b013e3181f79fa8. PMID: 20798655; PMCID: PMC3145631. Acute Calcium Ingestion Attenuates Exercise-induced Disruption of Calcium Homeostasis – PMC (nih.gov)

Shea KL, Barry DW, Sherk VD, Hansen KC, Wolfe P, Kohrt WM. Calcium supplementation and parathyroid hormone response to vigorous walking in postmenopausal women. Med Sci Sports Exerc. 2014 Oct;46(10):2007-13. doi: 10.1249/MSS.0000000000000320. PMID: 24576866; PMCID: PMC4145055. Calcium supplementation and parathyroid hormone response to vigorous walking in postmenopausal women – PubMed (nih.gov)

Aslam MN, Jepsen KJ, Khoury B, Graf KH, Varani J. Bone structure and function in male C57BL/6 mice: Effects of a high-fat Western-style diet with or without trace minerals. Bone Rep. 2016 Dec;5:141-149. doi: 10.1016/j.bonr.2016.05.002. PMID: 27350956; PMCID: PMC4920365. Bone structure and function in male C57BL/6 mice: Effects of a high-fat Western-style diet with or without trace minerals – PubMed (nih.gov)

Aslam MN, Bergin I, Jepsen K, Kreider JM, Graf KH, Naik M, Goldstein SA, Varani J. Preservation of bone structure and function by Lithothamnion sp. derived minerals. Biol Trace Elem Res. 2013 Dec;156(1-3):210-20. doi: 10.1007/s12011-013-9820-7. Epub 2013 Oct 6. PMID: 24096551; PMCID: PMC3905747. Preservation of bone structure and function by Lithothamnion sp. derived minerals – PubMed (nih.gov)

Aslam. A mineral-rich extract, Aquamin, from the red marine algae, Lithothamnion calcareum, preserves bone structure and function in female mice on a high fat diet. et al. (2010) Calcif Tissue Intl. 86(4) : 313-24

Heffernan SM, Horner K, De Vito G, Conway GE. The Role of Mineral and Trace Element Supplementation in Exercise and Athletic Performance: A Systematic Review. Nutrients. 2019 Mar 24;11(3):696. doi: 10.3390/nu11030696. PMID: 30909645; PMCID: PMC6471179. The Role of Mineral and Trace Element Supplementation in Exercise and Athletic Performance: A Systematic Review – PubMed (nih.gov)

Aslam, Muhammad & Varani, James. (2016). The Western-Style Diet, Calcium Deficiency and Chronic Disease. Journal of Nutrition & Food Sciences. 6. 10.4172/2155-9600.1000496. (PDF) The Western-Style Diet, Calcium Deficiency and Chronic Disease (researchgate.net)

Felice VD, O’Gorman DM, O’Brien NM, Hyland NP. Bioaccessibility and Bioavailability of a Marine-Derived Multimineral, Aquamin-Magnesium. Nutrients. 2018 Jul 17;10(7):912. doi: 10.3390/nu10070912. PMID: 30018220; PMCID: PMC6073474. Bioaccessibility and Bioavailability of a Marine-Derived Multimineral, Aquamin-Magnesium – PMC (nih.gov)

Brennan, Orlaith & Sweeney, Joseph & O’Meara, Brian & Widaa, Amro & Bonnier, Franck & Byrne, Hugh & O’Gorman, Denise & O’Brien, Fergal. (2017). A Natural, Calcium-Rich Marine Multi-mineral Complex Preserves Bone Structure, Composition and Strength in an Ovariectomised Rat Model of Osteoporosis. Calcified tissue international. 101. 10.1007/s00223-017-0299-7. (PDF) A Natural, Calcium-Rich Marine Multi-mineral Complex Preserves Bone Structure, Composition and Strength in an Ovariectomised Rat Model of Osteoporosis (researchgate.net)

Bae YJ, Bu SY, Kim JY, Yeon JY, Sohn EW, Jang KH, Lee JC, Kim MH. Magnesium supplementation through seaweed calcium extract rather than synthetic magnesium oxide improves femur bone mineral density and strength in ovariectomized rats. Biol Trace Elem Res. 2011 Dec;144(1-3):992-1002. doi: 10.1007/s12011-011-9073-2. Epub 2011 May 17. PMID: 21584658 Magnesium supplementation through seaweed calcium extract rather than synthetic magnesium oxide improves femur bone mineral density and strength in ovariectomized rats – PubMed (nih.gov)

Nielsen, Brian & Cate, Ryan & O’Connor-Robison, Cara. (2010). A Marine Mineral Supplement Alters Markers Of Bone Metabolism in Yearling Arabians. Journal of Equine Veterinary Science – J EQUINE VET SCI. 30. 419-424. 10.1016/j.jevs.2010.07.003. A Marine Mineral Supplement Alters Markers Of Bone Metabolism in Yearling Arabians | Request PDF (researchgate.net)

Heffernan SM, McCarthy C, Eustace S, FitzPatrick RE, Delahunt E, De Vito G. Mineral rich algae with pine bark improved pain, physical function and analgesic use in mild-knee joint osteoarthritis, compared to Glucosamine: A randomized controlled pilot trial. Complement Ther Med. 2020 May;50:102349. doi: 10.1016/j.ctim.2020.102349. Epub 2020 Feb 19. PMID: 32444040. Mineral rich algae with pine bark improved pain, physical function and analgesic use in mild-knee joint osteoarthritis, compared to Glucosamine: A randomized controlled pilot trial – PubMed (nih.gov)

Cronin BE, Allsopp PJ, Slevin MM, et al. Effects of supplementation with a calcium-rich marine-derived multi-mineral supplement and short-chain fructo-oligosaccharides on serum lipids in postmenopausal women. British Journal of Nutrition. 2016;115(4):658-665. doi:10.1017/S0007114515004948 Effects of supplementation with a calcium-rich marine-derived multi-mineral supplement and short-chain fructo-oligosaccharides on serum lipids in postmenopausal women | British Journal of Nutrition | Cambridge Core

Hampton AL, Aslam MN, Naik MK, Bergin IL, Allen RM, Craig RA, Kunkel SL, Veerapaneni I, Paruchuri T, Patterson KA, Rothman ED, Hish GA, Varani J, Rush HG. Ulcerative Dermatitis in C57BL/6NCrl Mice on a Low-Fat or High-Fat Diet With or Without a Mineralized Red-Algae Supplement. J Am Assoc Lab Anim Sci. 2015 Sep;54(5):487-96. PMID: 26424246; PMCID: PMC4587616. Ulcerative Dermatitis in C57BL/6NCrl Mice on a Low-Fat or High-Fat Diet With or Without a Mineralized Red-Algae Supplement – PubMed (nih.gov)

O’Callaghan YC, Drummond E, O’Gorman DM, O’Brien NM. Antioxidant and pro-apoptotic effects of marine-derived, multi-mineral aquamin supplemented with a pine bark extract, Enzogenol, and a green tea extract, Sunphenon. J Med Food. 2013 Oct;16(10):920-6. doi: 10.1089/jmf.2012.0258. Epub 2013 Sep 28. PMID: 24074358. Antioxidant and pro-apoptotic effects of marine-derived, multi-mineral aquamin supplemented with a pine bark extract, Enzogenol, and a green tea extract, Sunphenon – PubMed (nih.gov)

Aslam MN, Bhagavathula N, Paruchuri T, Hu X, Chakrabarty S, Varani J. Growth-inhibitory effects of a mineralized extract from the red marine algae, Lithothamnion calcareum, on Ca(2+)-sensitive and Ca(2+)-resistant human colon carcinoma cells. Cancer Lett. 2009 Oct 8;283(2):186-92. doi: 10.1016/j.canlet.2009.03.037. Epub 2009 Apr 24. PMID: 19394137; PMCID: PMC2770718. Growth-inhibitory effects of a mineralized extract from the red marine algae, Lithothamnion calcareum, on Ca(2+)-sensitive and Ca(2+)-resistant human colon carcinoma cells – PubMed (nih.gov)

Aslam MN, Paruchuri T, Bhagavathula N, Varani J. A mineral-rich red algae extract inhibits polyp formation and inflammation in the gastrointestinal tract of mice on a high-fat diet. Integr Cancer Ther. 2010 Mar;9(1):93-9. doi: 10.1177/1534735409360360. Epub 2010 Feb 11. PMID: 20150219; PMCID: PMC2861409 https://pubmed.ncbi.nlm.nih.gov/20150219/

Aslam MN, Bergin I, Naik M, Hampton A, Allen R, Kunkel SL, Rush H, Varani J. A multi-mineral natural product inhibits liver tumor formation in C57BL/6 mice. Biol Trace Elem Res. 2012 Jun;147(1-3):267-74. doi: 10.1007/s12011-011-9316-2. Epub 2012 Jan 6. PMID: 22222483; PMCID: PMC3360994. A multi-mineral natural product inhibits liver tumor formation in C57BL/6 mice – PubMed (nih.gov)

Aslam MN, Bergin I, Naik M, Paruchuri T, Hampton A, Rehman M, Dame MK, Rush H, Varani J. A multimineral natural product from red marine algae reduces colon polyp formation in C57BL/6 mice. Nutr Cancer. 2012;64(7):1020-8. doi: 10.1080/01635581.2012.713160. Epub 2012 Oct 4. PMID: 23035966; PMCID: PMC3660990. A multi-mineral natural product from red marine algae reduces colon polyp formation in C57BL/6 mice – PMC (nih.gov)

Aviello G, Amu S, Saunders SP, Fallon PG. A mineral extract from red algae ameliorates chronic spontaneous colitis in IL-10 deficient mice in a mouse strain dependent manner. Phytother Res. 2014 Feb;28(2):300-4. doi: 10.1002/ptr.4989. Epub 2013 Apr 4. PMID: 23554071. A mineral extract from red algae ameliorates chronic spontaneous colitis in IL-10 deficient mice in a mouse strain dependent manner – PubMed (nih.gov)

Crowley EK, Long-Smith CM, Murphy A, Patterson E, Murphy K, O’Gorman DM, Stanton C, Nolan YM. Dietary Supplementation with a Magnesium-Rich Marine Mineral Blend Enhances the Diversity of Gastrointestinal Microbiota. Mar Drugs. 2018 Jun 20;16(6):216. doi: 10.3390/md16060216. PMID: 29925774; PMCID: PMC6024889. Dietary Supplementation with a Magnesium-Rich Marine Mineral Blend Enhances the Diversity of Gastrointestinal Microbiota – PMC (nih.gov)

Aslam MN, Bassis CM, Bergin IL, Knuver K, Zick SM, Sen A, Turgeon DK, Varani J. A Calcium-Rich Multimineral Intervention to Modulate Colonic Microbial Communities and Metabolomic Profiles in Humans: Results from a 90-Day Trial. Cancer Prev Res (Phila). 2020 Jan;13(1):101-116. doi: 10.1158/1940-6207.CAPR-19-0325. Epub 2019 Nov 26. PMID: 31771942; PMCID: PMC7528938. https://pubmed.ncbi.nlm.nih.gov/31771942/

Dame MK, Veerapaneni I, Bhagavathula N, Naik M, Varani J. Human colon tissue in organ culture: calcium and multi-mineral-induced mucosal differentiation. In Vitro Cell Dev Biol Anim. 2011 Jan;47(1):32-8. doi: 10.1007/s11626-010-9358-3. Epub 2010 Nov 20. PMID: 21104039; PMCID: PMC3154723. Human colon tissue in organ culture: calcium and multi-mineral-induced mucosal differentiation – PubMed (nih.gov)

Singh N, Aslam MN, Varani J, Chakrabarty S. Induction of calcium sensing receptor in human colon cancer cells by calcium, vitamin D and aquamin: Promotion of a more differentiated, less malignant and indolent phenotype. Mol Carcinog. 2015 Jul;54(7):543-53. doi: 10.1002/mc.22123. Epub 2013 Dec 17. PMID: 26076051. Induction of calcium sensing receptor in human colon cancer cells by calcium, vitamin D and aquamin: Promotion of a more differentiated, less malignant and indolent phenotype – PubMed (nih.gov)

McClintock SD, Colacino JA, Attili D, Dame MK, Richter A, Reddy AR, Basrur V, Rizvi AH, Turgeon DK, Varani J, Aslam MN. Calcium-Induced Differentiation of Human Colon Adenomas in Colonoid Culture: Calcium Alone versus Calcium with Additional Trace Elements. Cancer Prev Res (Phila). 2018 Jul;11(7):413-428. doi: 10.1158/1940-6207.CAPR-17-0308. Epub 2018 Apr 10. PMID: 29636350; PMCID: PMC6030430. Calcium-Induced Differentiation of Human Colon Adenomas in Colonoid Culture: Calcium Alone versus Calcium with Additional Trace Elements – PubMed (nih.gov)

Attili D, McClintock SD, Rizvi AH, Pandya S, Rehman H, Nadeem DM, Richter A, Thomas D, Dame MK, Turgeon DK, Varani J, Aslam MN. Calcium-induced differentiation in normal human colonoid cultures: Cell-cell / cell-matrix adhesion, barrier formation and tissue integrity. PLoS One. 2019 Apr 17;14(4):e0215122. doi: 10.1371/journal.pone.0215122. PMID: 30995271; PMCID: PMC6469792. Calcium-induced differentiation in normal human colonoid cultures: Cell-cell / cell-matrix adhesion, barrier formation and tissue integrity – PubMed (nih.gov)

McClintock SD, Attili D, Dame MK, Richter A, Silvestri SS, Berner MM, Bohm MS, Karpoff K, McCarthy CL, Spence JR, Varani J, Aslam MN. Differentiation of human colon tissue in culture: Effects of calcium on trans-epithelial electrical resistance and tissue cohesive properties. PLoS One. 2020 Mar 5;15(3):e0222058. doi: 10.1371/journal.pone.0222058. PMID: 32134920; PMCID: PMC7058309. Differentiation of human colon tissue in culture: Effects of calcium on trans-epithelial electrical resistance and tissue cohesive properties – PubMed (nih.gov)

Magnesium

Magnesium (Mg) is essential and has a very important role in the structure and function of the human body.
An adult’s body contains about 25 grams of magnesium.
More than 60% of all magnesium present in the body is found in the skeleton, and about 27% in the muscles.
It also has a very important function at the nervous level. Sources legumes, cereals, green leafy vegetables, wheat bran, soybean flour, almonds, cashews, cane molasses, pumpkin seeds, pine nuts, and walnuts. Magnesium contributes to:

to the maintenance of bones in normal conditions.
to the maintenance of teeth in normal conditions.
to reduce tiredness and fatigue.
to electrolyte balance.
to normal energy metabolism.
to the normal functioning of the nervous system.
to the normal functioning of the muscles.
to normal protein synthesis.
to normal psychological function.
to the process of cell division.

Glucosamine

Glucosamine is a naturally occurring compound found in cartilage, the tough tissue that protects joints.
It is an aminomonosaccharide naturally present in human tissue and is a precursor to glycosaminoglycans and proteoglycans.
It can be said that both favor the development of cartilage tissues.
Glycosaminoglycans are components of the extracellular matrix and play an important role in cell proliferation and repair of damaged tissue.
Proteoglycans, on the other hand, promote the development of cartilage tissues, give volume and hydration to the skin and stimulate fibroblasts to produce more collagen.

OptiMSM® (MSM)

Methylsulfonylmethane, known as MSM, is an organic form of sulfur that helps strengthen connective tissue.
This compound is the third most abundant nutrient in the human body and is found in all vertebrates.
Some foods such as meat, vegetables, and dairy products also contain MSM. Sulphur is an essential nutrient for the body, but the recommended daily intake has not been established.
In the body, sulfur is found in connective tissues such as joints, is necessary for the formation of proteins, is a component of sulfur-containing amino acids, and is a component of enzymes and hormones. MSM is a chemical found naturally in humans, as well as in some green plants and animals, rich in sulfur, which is essential to connective tissues, skin and hair, and helps build and renew connective tissue. OptiMSM® is a registered trademark of MSM. OptiMSM® is the result of years of research, development, and continuous improvement.
It has a well-documented safety record and has been studied in a wide variety of investigations.

Joint Health: In studies, OptiMSM® has been shown to stimulate a significant reduction in pain and deterioration of the cartilage matrix in the joints.
OptiMSM’s® ability to improve mobility and modify the immune response was also revealed.
Inflammation: Researchers have observed that OptiMSM® can modify pro-inflammatory mechanisms to relieve exercise-induced pain and support antioxidant levels in the body.
Properties found in OptiMSM® can help prevent the buildup of oxidative damage that develops through aging and stress in the body.
Safety and effectiveness: Well-documented and studied for safety and efficacy, OptiMSM® is considered safe for humans and animals.
There is no known evidence of interactions between OptiMSM® and pharmaceuticals, herbs, vitamins, or minerals.

Why OptiMSM®?

Unmatched purity: A patented multi-stage distillation process ensures a product with 99.9% purity to ensure consistent, high-quality MSM.
Safety: The only vegan, non-GMO, gluten-free, allergen-free, and shellfish-free MSM, designated GRAS, Kosher and Halal certified, backed by extensive toxicological data.
ISO 9001:2015, FSSC 220000 certification, HACCP and cGMP compliance.

Muizzuddin N, Benjamin R. Beauty from within: Oral administration of a sulfur-containing supplement methylsulfonylmethane improves signs of skin ageing. Int J Vitam Nutr Res. 2022 Jul;92(3-4):182-191. doi: 10.1024/0300-9831/a000643. Epub 2020 Feb 21. PMID: 32083522.

Guaitolini E, Cavezzi A, Cocchi S, Colucci R, Urso SU, Quinzi V. Randomized, Placebo-controlled Study of a Nutraceutical Based on Hyaluronic Acid, L-carnosine, and Methylsulfonylmethane in Facial Skin Aesthetics and Well-being. J Clin Aesthet Dermatol. 2019 Apr;12(4):40-45. Epub 2019 Apr 1. PMID: 31119010; PMCID: PMC6508480.

Muizzuddin, Neelam & Benjamin, Rodney. (2020). Beneficial Effects of a Sulfur-Containing Supplement on Hair and Nail Condition [1] A prospective, double-blind study in middle-aged women.

van der Merwe M, Bloomer RJ. The Influence of Methylsulfonylmethane on Inflammation-Associated Cytokine Release before and following Strenuous Exercise. J Sports Med (Hindawi Publ Corp). 2016;2016:7498359. doi: 10.1155/2016/7498359. Epub 2016 Oct 23. PMID: 27844051; PMCID: PMC5097813.

Peel, Shelby & Melcher, Daniel & Schilling, Brian & Bloomer, Richard & Paquette, Max. (2015). The Effects of MSM Supplementation on Knee Kinetics during Running, Muscle Strength, and Muscle Soreness following Eccentric Exercise-Induced Quadriceps Damage.

Withee ED, Tippens KM, Dehen R, Tibbitts D, Hanes D, Zwickey H. Effects of Methylsulfonylmethane (MSM) on exercise-induced oxidative stress, muscle damage, and pain following a half-marathon: a double-blind, randomized, placebo-controlled trial. J Int Soc Sports Nutr. 2017 Jul 21;14:24. doi: 10.1186/s12970-017-0181-z. PMID: 28736511; PMCID: PMC5521097.

Kalman, Douglas S. et al. “A Randomized Double Blind Placebo Controlled Evaluation of MSM for Exercise Induced Discomfort/Pain.” The FASEB Journal 27 (2013): n. pag.

Kalman D. Inﬂuence of MSM on Markers of Exercise Recovery and Performance and Total Antioxidant Capacity. J. of Int. Society of Sports Nut. 2012, 9:46

Marañón G, Muñoz-Escassi B, Manley W, García C, Cayado P, de la Muela MS, Olábarri B, León R, Vara E. The effect of methyl sulphonyl methane supplementation on biomarkers of oxidative stress in sport horses following jumping exercise. Acta Vet Scand. 2008 Nov 7;50(1):45. doi: 10.1186/1751-0147-50-45. PMID: 18992134; PMCID: PMC2586020.

Daniel A. MELCHER, Sang-Rok LEE, Shelby A. PEEL, Max R. PAQUETTE, Richard J. BLOOMER. Effects of methylsulfonylmethane supplementation on oxidative stress, muscle soreness, and performance variables following eccentric exercise. Gazzetta Medica Italiana Archivio per le Scienze Mediche 2017 May;176(5):271-83. DOI: 10.23736/S0393-3660.16.03346-5

Hasegawa, T. & Ueno, S. & Kumamoto, S. & Yoshikai, Y.. (2004). Suppressive effect of methylsulfonylmethane (MSM) on type II collagen-induced arthritis in DBA/1J mice. Japanese Pharmacology and Therapeutics. 32. 421-427.

DeSilvestro et al. 2008. MSM intake in Mice Produces Elevated Liver Glutathione and Partially Protects against CCl4 -Induced Liver Damage. FASEB J, 2008, 22:445.8

Radwan. Actions of Taurine, Methylsulfonylmethane and Silymarin Against Acetaminophen- Induced Neuro- and Hepato-Toxicity in Rat. J of Biomed and Pharma Res, 2016, 5(3):10-17

Mohammadi S, Najafi M, Hamzeiy H, Maleki-Dizaji N, Pezeshkian M, Sadeghi-Bazargani H, Darabi M, Mostafalou S, Bohlooli S, Garjani A. Protective effects of methylsulfonylmethane on hemodynamics and oxidative stress in monocrotaline-induced pulmonary hypertensive rats. Adv Pharmacol Sci. 2012;2012:507278. doi: 10.1155/2012/507278. Epub 2012 Oct 15. PMID: 23118745; PMCID: PMC3478703.

Bohlooli S, Mohammadi S, Amirshahrokhi K, Mirzanejad-Asl H, Yosefi M, Mohammadi-Nei A, Chinifroush MM. Effect of Methylsulfonylmethane Pretreatment on Aceta-minophen Induced Hepatotoxicity in Rats. Iran J Basic Med Sci. 2013 Aug;16(8):896-900. PMID: 24106592; PMCID: PMC3786100.

Godwin S, Bloomer RJ, van der Merwe M, Benjamin R. MSM enhances LPS-induced inflammatory response after exercise. J Int Soc Sports Nutr. 2015 Sep 21;12(Suppl 1):P48. doi: 10.1186/1550-2783-12-S1-P48. PMCID: PMC4595096.

Hasegawa, T. & Ueno, S. & Kumamoto, S.. (2005). Anti-inflammatory effect of methylsulfonylmethane (MSM) in mice. Japanese Pharmacology and Therapeutics. 33. 1217-1223.

Barrager E, Veltmann JR Jr, Schauss AG, Schiller RN. A multicentered, open-label trial on the safety and efficacy of methylsulfonylmethane in the treatment of seasonal allergic rhinitis. J Altern Complement Med. 2002 Apr;8(2):167-73. doi: 10.1089/107555302317371451. PMID: 12006124.

Hewlings S, Kalman DS. Evaluating the Impacts of Methylsulfonylmethane on Allergic Rhinitis After a Standard Allergen Challenge: Randomized Double-Blind Exploratory Study. JMIR Res Protoc. 2018 Nov 29;7(11):e11139. doi: 10.2196/11139. PMID: 30497995; PMCID: PMC6293242.

Hyaluronic acid

Hyaluronic acid is a polysaccharide found in the epidermis, connective tissue, cartilage, synovial fluid, eyes, and many other organs and tissues. As we age, the synthesis of hyaluronic acid decreases and its presence in the body decreases over the years.
This is what causes us to have greater stiffness in the joints, less hydration and lubrication in the cartilage and a less flexible skin full of wrinkles. It acts as a ‘storehouse’ for water molecules, so its main function is to retain water and keep the organs that contain it hydrated.

MenaQ7® (Vitamin K)

Vitamin K is a fat-soluble vitamin that occurs naturally in two forms: vitamin K1 (phylloquinone) and vitamin K2.
Both vitamins have the same structure, the difference lies in the active part of the molecule that determines its action and half-life. The source of K1 in the diet is found in leafy greens such as spinach, broccoli, Brussels sprouts, cabbage, and lettuce.
Vitamin K2, a term used for a group of compounds called ‘menaquinones’, is found mainly in dairy products.
In the body, vitamin K1 is concentrated in the liver and is essential for blood clotting and has a half-life in the body of 1:30h.
K2, on the other hand, has a half-life of 72 hours, so it allows proteins to be activated outside the liver and fulfill its function in the activation of bone proteins.
As such, vitamin K2 is found in extrahepatic tissues such as bones, cartilage, and arteries, where it plays an important role in regulating calcium metabolism. Among its functions, vitamin K contributes:

to normal blood clotting.
to the maintenance of bones in normal conditions.

MenaQ7® is a vitamin K2 as menaquinone-7 (MK-7) is the most bioavailable, longest-lasting, and most bioactive form of vitamin K. MenaQ7® is the ONLY effective vitamin K supplement within current RDAs, which has been shown to be safe and effective at only 45 mcg daily. MenaQ7® is the only clinically validated and patented vitamin K2 like MK-7 available on the market today.
In addition, MenaQ7® varieties are suitable for vegans and vegetarians, free of gluten, dairy, soy and other known allergens.

Zwakenberg SR, de Jong PA, Bartstra JW, van Asperen R, Westerink J, de Valk H, Slart RHJA, Luurtsema G, Wolterink JM, de Borst GJ, van Herwaarden JA, van de Ree MA, Schurgers LJ, van der Schouw YT, Beulens JWJ. The effect of menaquinone-7 supplementation on vascular calcification in patients with diabetes: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2019 Oct 1;110(4):883-890. doi: 10.1093/ajcn/nqz147. PMID: 31387121; PMCID: PMC6766434. The effect of menaquinone-7 supplementation on vascular calcification in patients with diabetes: a randomized, double-blind, placebo-controlled trial – PMC (nih.gov)

Mansour AG, Hariri E, Daaboul Y, Korjian S, El Alam A, Protogerou AD, Kilany H, Karam A, Stephan A, Bahous SA. Vitamin K2 supplementation and arterial stiffness among renal transplant recipients-a single-arm, single-center clinical trial. J Am Soc Hypertens. 2017 Sep;11(9):589-597. doi: 10.1016/j.jash.2017.07.001. Epub 2017 Jul 13. PMID: 28756183. Vitamin K2 supplementation and arterial stiffness among renal transplant recipients-a single-arm, single-center clinical trial – PubMed (nih.gov)

Aoun M, Makki M, Azar H, Matta H, Chelala DN. High Dephosphorylated-Uncarboxylated MGP in Hemodialysis patients: risk factors and response to vitamin K2, A pre-post intervention clinical trial. BMC Nephrol. 2017 Jun 7;18(1):191. doi: 10.1186/s12882-017-0609-3. PMID: 28592319; PMCID: PMC5463325. High Dephosphorylated-Uncarboxylated MGP in Hemodialysis patients: risk factors and response to vitamin K2, A pre-post intervention clinical trial – PubMed (nih.gov)

Knapen MH, Braam LA, Teunissen KJ, Van’t Hoofd CM, Zwijsen RM, van den Heuvel EG, Vermeer C. Steady-state vitamin K2 (menaquinone-7) plasma concentrations after intake of dairy products and soft gel capsules. Eur J Clin Nutr. 2016 Jul;70(7):831-6. doi: 10.1038/ejcn.2016.3. Epub 2016 Feb 24. PMID: 26908424. Steady-state vitamin K2 (menaquinone-7) plasma concentrations after intake of dairy products and soft gel capsules – PubMed (nih.gov)

Knapen MH, Braam LA, Teunissen KJ, Zwijsen RM, Theuwissen E, Vermeer C. Yogurt drink fortified with menaquinone-7 improves vitamin K status in a healthy population. J Nutr Sci. 2015 Oct 16;4:e35. doi: 10.1017/jns.2015.25. PMID: 26495126; PMCID: PMC4611080. Yogurt drink fortified with menaquinone-7 improves vitamin K status in a healthy population – PubMed (nih.gov)

Kurnatowska I, Grzelak P, Masajtis-Zagajewska A, Kaczmarska M, Stefańczyk L, Vermeer C, Maresz K, Nowicki M. Effect of vitamin K2 on progression of atherosclerosis and vascular calcification in nondialyzed patients with chronic kidney disease stages 3-5. Pol Arch Med Wewn. 2015;125(9):631-40. doi: 10.20452/pamw.3041. Epub 2015 Jul 15. PMID: 26176325. Effect of vitamin K2 on progression of atherosclerosis and vascular calcification in nondialyzed patients with chronic kidney disease stages 3-5 – PubMed (nih.gov)

Knapen MH, Braam LA, Drummen NE, Bekers O, Hoeks AP, Vermeer C. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial. Thromb Haemost. 2015 May;113(5):1135-44. doi: 10.1160/TH14-08-0675. Epub 2015 Feb 19. PMID: 25694037. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial – PubMed (nih.gov)

Theuwissen E, Cranenburg EC, Knapen MH, Magdeleyns EJ, Teunissen KJ, Schurgers LJ, Smit E, Vermeer C. Low-dose menaquinone-7 supplementation improved extra-hepatic vitamin K status, but had no effect on thrombin generation in healthy subjects. Br J Nutr. 2012 Nov 14;108(9):1652-7. doi: 10.1017/S0007114511007185. Epub 2012 Jan 31. PMID: 22289649. Low-dose menaquinone-7 supplementation improved extra-hepatic vitamin K status, but had no effect on thrombin generation in healthy subjects – PubMed (nih.gov)

Dalmeijer GW, van der Schouw YT, Magdeleyns E, Ahmed N, Vermeer C, Beulens JW. The effect of menaquinone-7 supplementation on circulating species of matrix Gla protein. Atherosclerosis. 2012 Dec;225(2):397-402. doi: 10.1016/j.atherosclerosis.2012.09.019. Epub 2012 Sep 25. PMID: 23062766. The effect of menaquinone-7 supplementation on circulating species of matrix Gla protein – PubMed (nih.gov)

Knapen MH, Drummen NE, Smit E, Vermeer C, Theuwissen E. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporos Int. 2013 Sep;24(9):2499-507. doi: 10.1007/s00198-013-2325-6. Epub 2013 Mar 23. PMID: 23525894. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women – PubMed (nih.gov)

Ozdemir MA, Yilmaz K, Abdulrezzak U, Muhtaroglu S, Patiroglu T, Karakukcu M, Unal E. The efficacy of vitamin K2 and calcitriol combination on thalassemic osteopathy. J Pediatr Hematol Oncol. 2013 Nov;35(8):623-7. doi: 10.1097/MPH.0000000000000040. PMID: 24136015. The efficacy of vitamin K2 and calcitriol combination on thalassemic osteopathy – PubMed (nih.gov)

van Summeren MJ, Braam LA, Lilien MR, Schurgers LJ, Kuis W, Vermeer C. The effect of menaquinone-7 (vitamin K2) supplementation on osteocalcin carboxylation in healthy prepubertal children. Br J Nutr. 2009 Oct;102(8):1171-8. doi: 10.1017/S0007114509382100. Epub 2009 May 19. PMID: 19450370. The effect of menaquinone-7 (vitamin K2) supplementation on osteocalcin carboxylation in healthy prepubertal children – PubMed (nih.gov)

Rogier Caluwé, Stefaan Vandecasteele, Bruno Van Vlem, Cees Vermeer, An S. De Vriese, Vitamin K2 supplementation in haemodialysis patients: a randomized dose-finding study, Nephrology Dialysis Transplantation, Volume 29, Issue 7, July 2014, Pages 1385–1390, https://doi.org/10.1093/ndt/gft464

Westenfeld R, Krueger T, Schlieper G, Cranenburg EC, Magdeleyns EJ, Heidenreich S, Holzmann S, Vermeer C, Jahnen-Dechent W, Ketteler M, Floege J, Schurgers LJ. Effect of vitamin K2 supplementation on functional vitamin K deficiency in hemodialysis patients: a randomized trial. Am J Kidney Dis. 2012 Feb;59(2):186-95. doi: 10.1053/j.ajkd.2011.10.041. Epub 2011 Dec 9. PMID: 22169620. Effect of vitamin K2 supplementation on functional vitamin K deficiency in hemodialysis patients: a randomized trial – PubMed (nih.gov)

Theuwissen E, Magdeleyns EJ, Braam LA, Teunissen KJ, Knapen MH, Binnekamp IA, van Summeren MJ, Vermeer C. Vitamin K status in healthy volunteers. Food Funct. 2014 Feb;5(2):229-34. doi: 10.1039/c3fo60464k. PMID: 24296867. Vitamin K status in healthy volunteers – PubMed (nih.gov)

Sato et al. Nutrition Journal. 2012 – Search Results – PubMed (nih.gov)

Schurgers LJ, Teunissen KJ, Hamulyák K, Knapen MH, Vik H, Vermeer C. Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. Blood. 2007 Apr 15;109(8):3279-83. doi: 10.1182/blood-2006-08-040709. Epub 2006 Dec 7. PMID: 17158229. Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7 – PubMed (nih.gov)

Vitamin D₃

Vitamin D is a fat-soluble vitamin that plays an important role in bone metabolism and has anti-inflammatory and immunomodulatory properties. Vitamin D3 can be obtained by sun exposure (90%) and through diet (10%).
However, its cutaneous synthesis is not enough to reach the optimal levels to improve our state of health. The richest natural sources of vitamin D are fish liver oils and saltwater fish, such as sardines, herring, salmon, and mackerel.
Eggs, meat, milk, and butter contain small amounts. The sun, on the other hand, is a source of vitamin D. However, various factors such as sunscreens with a protection factor greater than 8, age, darker pigmentation, a northern latitude greater than 40 degrees and the winter season reduce the production of vitamin D in the skin. Among the functions, vitamin D contributes to:

to the normal absorption and utilization of calcium and phosphorus.
to the maintenance of normal blood calcium levels.
to the maintenance of bones in normal conditions.
to the normal functioning of the muscles.
to the maintenance of teeth in normal conditions.
to the normal functioning of the immune system.
to the process of cell division.

Product Description

Nutritional information

Description

Foods needed for bone maintenance We all know that calcium is one of the minerals necessary for bone formation and therefore there is a recommendation to take dairy products.
However, there are other foods that are rich in calcium and contain other essential micronutrients.
Sardines, for example, are a rich source of calcium, but they are also rich in vitamin D, a vitamin necessary for intestinal absorption of calcium.
And on the other hand, green leafy vegetables such as spinach, kale, broccoli and lettuce are rich in vitamin K which has the function of helping calcium crystallize in the bone.

How to take Procollagen Plus

1 measuring spoon (11 g) per day Mix the contents of one measuring spoon in a glass of water, dairy or vegetable drink (200ml), stir and drink after breakfast or lunch.

Presentation

330 g (30 servings)

Indications

Contributes to normal collagen formation.
Contributes to the normal functioning and maintenance of bones and cartilage.
Contributes to the normal formation of connective tissue.

Ingredients

Hydrolyzed Fish Collagen, Lithothamnion Calcareum (Pallas) Areschoug Algae Thallus Powder, (32% Calcium), Magnesium Citrate, Calcium L-Ascorbate, Flavoring, Inulin, D-Glucosamine Sulfate 2 KCL, MSM (Methylsulfonylmethane), L-Arginine Base, L-Lysine HCl, Sodium Hyaluranate (95% Hyaluronic Acid), Pomegranate Fruit Dry Extract (Punica granatum L.) 40% Ellagic Acid, Bamboo Stem and Leaf Dry Extract (Bambusa vulgaris Schrad.) 85% silicon, dried extract of orange fruit (Citrus sinensis (L.)
Osbeck) 60% hesperidin, menaquinone, L-selenomethionine, zinc bisglycinate, cholecalciferol, sweetener: steviol glycosides from stevia, manganese citrate, cupric gluconate.

Contraindications / Allergens

Contains fish.

Warnings

Food supplements should not be used as substitutes for a varied and balanced diet or a healthy lifestyle.
Do not exceed the recommended daily dose.
Keep out of reach of young children.

Contains fish

Gluten free

Lactose free

Nutritional Information

Ingredients	1 Serving (11g)	%NRV
Hydrolyzed Fish Collagen (Peptan® F 5000 LD)	5000 mg
Calcium (from Lithothamnion calcareum Aquamin™ algae)	800 mg	100%
Vitamin C (calcium l-ascorbate)	500 mg	625%
Inulin	310 mg
Magnesium (citrate)	300 mg	80%
D-glucosamine sulfate 2 KCL, of which	267 mg
-Glucosamine	200 mg
MSM (Methylsulfonylmethane - OptiMSM®)	200 mg
L-arginine base	200 mg
L-lysine HCl	200 mg
Hyaluronic acid	100 mg
Pomegranate extract (Punica granatum L.), of which	100 mg
- Ellagic acid	40 mg
Bamboo Extract (Bambusa vulgaris Schrad.), of which	41 mg
-Silicon	35 mg
Orange Tree Extract (Citrus sinensis (L.) Osbeck), of which	33.33 mg
-Hesperidin	20 mg
Zinc (bisglycinate)	5 mg	50%
Manganese (citrate)	0.47 mg	23,5%
Copper (cupric gluconate)	0.25 mg	25%
Selenium (selenomethionine)	100 μg	181,81%
Vitamin K₂ (menaquinone-7)	50 μg	66,7%
Vitamin D₃ (cholecalciferol)	25 μg	500%

NRV: Nutrient Reference Value.
*%NRV not defined.

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