Cardisterol

Active Omega 3
National Code: 185521.3

60 Pearls

Dietary supplement based on Omega 3, red rice yeast, policosanol, coenzyme Q10 and B vitamins for normal heart function and maintenance of normal homocysteine levels.

Product Features

Cardisterol
Contains fish
Cardisterol
Gluten free
Cardisterol
Lactose free

Product benefits

Heart
Cardiovascular Health
Homocysteine control
Omega 3

Product Features

Cardisterol
Contains fish
Cardisterol
Gluten free
Cardisterol
Lactose free

Main assets ofCardisterol

Fish oil (SLTEX)

Each pearl contains 850 mg of fish oil, of which 425 mg is EPA (eicosapentaenoic acid).

EPA

(Eicosapentaenoic acid)
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) contribute to the normal function of the heart.

Vitamin E

(D-alpha-tocopherol)
Contributes to the protection of cells against oxidative damage.

Monacolina K

Monacolin K is a metabolite obtained from the fermentation of red yeast rice.

Coenzyme Q10 (CoQ10)

CoQ10 is an antioxidant that the body synthesizes, but whose levels decrease as you age.

Sugarcane Extract

(Saccharum officinarum L)
Policosanol obtained from sugar cane wax can help in reducing cholesterol levels.

Quatrefolic® (Vitamin B9 or Folate or Folic Acid)

(5-methyltetrahydrofolate)
Contributes to the normal metabolism of homocysteine.

Vitamin B12 or Methylcobalamin

(Methylcobalamin)
Contributes to the normal metabolism of homocysteine.
Stress Control
Fish oil (SLTEX)

From a nutritional point of view, fish are classified according to their fat content: fatty or oily fish, semi-fatty and lean or white.
Only fatty or semi-fatty fish contain high levels of Omega 3, the best known of which are EPA and DHA.
These fatty acids have been shown to be beneficial to health. This fish oil has the SLTEX seal, a seal of the Solutex GC company that guarantees the highest criteria of purity and quality when obtaining specialties aimed at human consumption; through the use of a unique supercritical CO2 extraction and purification fluid technology.
It also guarantees Omega 3, both EPA and DHA, in very high purity and concentration.
The high concentration of EPA and DHA means greater absorption and incorporation by our body. Omega 3 are a type of essential fatty acids that cannot be synthesized by the body and therefore must be incorporated through the diet.
To meet the daily needs of this nutrient, it is often necessary to resort to the consumption of food supplements, especially in stages when these requirements increase, such as pregnancy(1). Long-chain polyunsaturated fatty acids (EPA and DHA) are primarily produced from marine microalgae before entering the fish food chain.
These microalgae have the enzymes necessary to efficiently synthesize DHA, from the fatty acid α-linolenic acid (ALA).
However, the ALA (precursor of EPA and DHA) obtained from the diet produces little DHA in the human body, so to obtain DHA it is more effective to consume oily fish or take a dietary supplement of Omega 3 fatty acids(2). Omega-3s are mostly found in oily fish such as salmon, mackerel, tuna, herring and sardines.
They are also found in nuts and seeds (such as flaxseed, chia seeds, and walnuts). Docosahexaenoic acid (DHA) is an omega-3 fatty acid with anti-inflammatory properties and an important role in brain and vision development.
Eicosapentaenoic acid (EPA), on the other hand, is an omega 3 precursor of anti-inflammatory substances and is especially important for the cardiovascular system, but it can also be effective at the musculoskeletal, joint, dermatological level, etc. Docosahexaenoic acid (DHA) contributes:

  • to maintain normal brain function.
  • to the maintenance of vision under normal conditions.

The beneficial effect is obtained with an intake of 250 mg of DHA.

 

Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) contribute:

  • to the normal functioning of the heart.
EPA

EPA is an omega-3 fatty acid that contributes to heart function.
Omega-3s are essential for the body and are obtained through food, mostly oily fish, nuts and seeds.
Specifically, EPA is a precursor of anti-inflammatory substances that are part of the prostaglandin family.
EPA is especially important for the cardiovascular system, but it can also be effective at the musculoskeletal, joint, dermatological level, etc.
On the other hand, EPA (eicosapentaenoic acid) participates in the modulation of the immune response, helping to reduce inflammation and anatomical-functional damage, showing its anti-inflammatory effect.
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) contribute:

  • to the normal functioning of the heart.
Vitamin E

Vitamin E is a fat-soluble nutrient found in many foods.
It is a very effective antioxidant capable of protecting the body against oxidative damage.
Specifically, it has been proven that it protects unsaturated fatty acids and other easily oxidizable substances.
It also acts in the body by stabilizing other vitamins, particularly vitamin A, as well as other hormones and enzymes.
The biological activity of vitamin E in food depends on the presence of the different tocopherols.
The most important sources of vitamin E are vegetable oils (olive, soybean, palm, strip, sunflower, etc.), nuts, whole grains and wheat germ.
Other sources are seeds and green leafy vegetables.
In relation to omega 3, it seems to play a fundamental role in protecting the cell membrane from free radical reactions and peroxidation of polyunsaturated fatty acids.
Among its functions, vitamin E contributes:

  • to the protection of cells against oxidative damage.
Monacolina K

Monacolin K is a metabolite obtained from the fermentation of red rice with the yeast Monacus purpureus, traditionally used in Chinese medicine to lower blood lipid levels. Red yeast rice could contain compounds that would lower cholesterol levels since its molecule has a chemical structure very similar to lovastatin, a drug used for high cholesterol. Scientific studies have shown that monacolin k has a similar effect to lovastatin in improving the lipid profile, but with fewer side effects.

Coenzyme Q10 (CoQ10)

Coenzyme Q10 (CoQ10), also known as ubiquinone, is a vitamin-like substance found within the mitochondria of every cell in the body. Mitochondria are responsible for extracting approximately 50% of the total energy that comes from the food we eat.
That is why CoQ10 plays a fundamental role in mitochondrial metabolism, specifically it is part of the mitochondrial electron transport chain.
It promotes the conversion of nutrients into ATP (energy molecules). It is an important antioxidant found in high amounts in organs that need more energy, such as muscles, heart, tissues, and liver. CoQ10 is found in foods such as organ meats, but cooking tends to destroy it.
Our body also manufactures it, however, as we age, production decreases.
In fact, the lack of energy in older people may, to some extent, be related to this decrease in CoQ10.
That is why its intake in the form of food supplements is so recommended. It appears that CoQ10 levels may also be lower in people on cholesterol-lowering statins because statins block their synthesis.
On the other hand, studies suggest that CoQ10 can inhibit lipid oxidation by protecting them.

Sugarcane Extract

Sugar cane extract is used to obtain policosanol and octacosanol, a mixture of long-chain aliphatic alcohols. Since the 90s when it was discovered, different clinical studies have been carried out to evaluate the effect of policosanol and octacosanol in reducing cholesterol levels.
Thus, different studies indicate that both can help maintain normal levels of bad cholesterol (LDL) in the blood, reduce total cholesterol and increase good cholesterol (HDL).

Quatrefolic® (Vitamin B9 or Folate or Folic Acid)

Vitamin B9, also called folate, is one of the water-soluble B vitamins.
Its name comes from the word “folia” which means leaf in Latin, due to its natural presence in green leafy vegetables.
Also in beans, wheat germ and yeast.
Other sources include egg yolk, milk and dairy, beetroot, orange juice, and wholemeal bread.
Vitamin B9 is given in different forms: the natural one which is folate and folic acid, which is a synthetic folate compound used in vitamin supplements and fortified foods because it is more stable. Folic acid contributes:

  • to normal homocysteine metabolism.
  • to the growth of maternal tissues during pregnancy.
  • to normal amino acid synthesis.
  • to the normal formation of blood cells.
  • to normal psychological function.
  • to the normal functioning of the immune system.
  • Helps to reduce tiredness and fatigue.
  • to the process of cell division.

In food supplements, folate is usually found in the form of folic acid, but different salts such as 5-MTHF (methylfolate) can also be used.
Quatrefolic® glucosamine salt (6S)-5-methyltetrahydrofolate (5-MTHF).
The source of folic that is selected is very important.
Dietary supplements containing 5-MTHF may be better than folic acid for some people who have a gene mutation called MTHFR C677T because their bodies can use this form more easily.
This is because the body cannot transform the synthetic folic or folic present in fruits and vegetables into its methylated active form.
That is why our formulas contain Quatrefolic® (5-MTHF). Quatrefolic® is a fourth-generation folate.
It is a registered trademark of Vitamin B9, (also known as Folate).
It is the glucosamine salt of (6S)-5-methyltetrahydrofolate (5-MTHF) and is structurally identical to the reduced, active form of folate found in our bodies. It is an innovative dietary ingredient that provides greater stability, improved bioavailability, higher water solubility, and flexibility for multi-ingredient formulations compared to a third-generation 5-MTHF calcium salt. In recent years, more and more evidence has been found of the advantages of reduced folate over folic acid.
The use of reduced folate (particularly reduced and methylated as Quatrefolic®) is the solution since a large part of the world’s population cannot assimilate and metabolize folic acid from foods or food supplements.
Quatrefolic® is manufactured under controlled conditions according to cGMP and since glucosamine does not come from animals or shellfish, Quatrefolic ® is a great choice for vegetarians.
In addition, Quatrefolic® is considered safe and is recognized as GRAS.

1. Patanwala I et al. Folic acid handling by the human gut: implications for food fortification and supplementation. Am J Clin Nutr. 2014

2. Scaglione F, Panzavolta G. Folate, folic acid and 5-methyltetrahydrofolate are not the same thing. Xenobiotica. 2014

3. Ulrich CM, Potter JD. Folate supplementation: too much of a good thing? Cancer Epidemiol Biomarkers Prev. 2006

4. Pietrzik K et al. Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics. Clin Pharmacokinet. 2010

5. Lawrence, Kripalani et al. « Profiling National Mandatory Folic Acid Fortification Policy Around the World. » New York: Springer; 2012

6. Ulric et al. « Folate Supplementation: Too Much of a Good Thing? » Cancer Epidemiol Biomarkers Prev 2006;15:189-193

7. Strum et al. « Enzymatic reduction and methylation of folate following pH-dependant, carrier-mediated transport in rat jejunum. » Biochim Biophys Acta 1979; 554, 249-257

8. Kelly et al. « Unmetabolized folic acid in serum: acute studies in subjects consuming fortified food and supplements. » Am J Clin Nutr 1997:65:1790-5

9. Jamil K. Clinical Implications of MTHFR Gene Polymorphism in Various Diseases. Biol Med. 2014

10. Wilcken B et al. Geographical and ethnic variation of the 677C>T allele of 5,10 methylenetetrahydrofolate reductase (MTHFR): findings from over 7000 newborns from 16 areas worldwide. J Med Genet. 2003

11. Seremak-Mrozikiewicz A et al. The significance of 1793G>A polymorphism in MTHFR gene in women with first trimester recurrent miscarriages. Neuro Endocrinol Lett. 2010

12. Tsang BL et al. Assessing the association between the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism and blood folate concentrations: A systematic review and meta-analysis of trials and observational studies. Am. J. Clin. Nutr. 2015

13. Sweeney MR et al. Persistent circulating unmetabolized folic acid in a setting of liberal voluntary folic acid fortification. Implications for further mandatory fortification? BMC Public Health. 2009

14. Smith AD. Folic acid fortification: the good, the bad, and the puzzle of vitamin B-12. Am J Clin Nutr. 2007

15. Smith D. A. et al. Is folic acid good for everyone? Am J Clin Nutr. 2008

16. Colman, Green, Metz et al. « Prevention of folate deficiency by food fortification. Il. Absorption of folic acid from staple foods. » Am J Clin Nutr I 975; 28:459-64

17. Shils et al. « Modern Nutrition in Health and Disease, 9th ed ». Williams & Wilkins, Balt., 1999

18. http://www.efsa.europa.eu/it/home/publication/efsafolicacid.pdf

19. Morris MS et al. « Circulating unmetabolized folic acid and 5-methyltetrahydrofolate in relation to anemia, macrocytosis, and cognitive test performance in American seniors ». Am J Clin Nutr. 2010

Vitamin B12 or Methylcobalamin

Vitamin B12 is the largest and most complex of the vitamins.
Vitamin B12 comprises the only cobalt-containing molecules (called cobalamins) with biological activity in humans. Vitamin B12 is produced exclusively by microbial synthesis in the digestive tract of animals.
Therefore, people who follow a vegetarian or vegan diet have to provide this vitamin through food supplements. It is obtained from products with animal proteins, especially organ meats.
Other good sources include fish, eggs, and dairy products. Among its functions, vitamin B12 contributes:

  • to normal homocysteine metabolism.
  • to normal energy metabolism.
  • to the normal functioning of the nervous system.
  • to normal psychological function.
  • to the normal formation of red blood cells.
  • to the normal functioning of the immune system.
  • Helps to reduce tiredness and fatigue.
  • to the process of cell division.

Product Description

Nutritional information

Description

Why is proper nutrition important for heart health? Cardiovascular health is closely linked to food.
Although there may be genetic conditions that contribute to high cholesterol and triglyceride levels, diet also plays a role.
It is recommended to reduce the consumption of saturated fats from red meat, chicken and chicken skin, sausages, and simple carbohydrates.
On the other hand, it is recommended to increase the consumption of fish, especially blue fish, as it contains omega 3 that contributes to the normal functioning of the heart.
In addition to the classic markers of cardiovascular risk such as cholesterol and triglycerides, homocysteine in the blood is considered an independent marker of risk.
vitamin B6, B12 and folate contribute to the normal metabolism of homocysteine in the blood.

How to take Cardisterol

1 pearl, at dinner.
Avoid consumption with grapefruit juice.

Presentation

60 Pearls

Indications

  • Contributes to the normal functioning of the heart.
  • Maintenance of normal homocysteine levels.

Ingredients

Fish oil, capsule (fish gelatin, humectant: glycerin, water, colourings: black iron oxide and red iron oxide), red yeast rice (Monascus purpureus, 5% monacolin K), coenzyme Q10, emulsifier: sunflower lecithin, dry extract of sugar cane (Saccharum officinarum L., 98% policosanol, 10% octacosanol), thickener: yellow beeswax, D-alpha-tocopherol, pyridoxal 5′-phosphate, folic acid Quatrefolic® ((6S)-5-methyltetrahydrofolic acid, glucosamine salt), methylcobalamin.

Contraindications / Allergens

Contains fish.
Avoid consumption with grapefruit juice.
It should not be consumed if you are taking cholesterol-lowering medications or other products containing red yeast rice.

Warnings

Dietary supplements should not be used as substitutes for a varied and balanced diet or a healthy lifestyle.
Do not exceed the recommended daily dose.
Keep out of reach of young children.
It should not be consumed by pregnant or breastfeeding women, people under 18 years of age or over 70.
Seek medical advice regarding the consumption of this product, if you suffer from any health problems.
It should not be consumed together with cholesterol-lowering medication.
It should not be consumed if other products containing red yeast rice are already consumed.

Cardisterol
Contains fish
Cardisterol
Gluten free
Cardisterol
Lactose free
Nutritional Information
Ingredients1 pearl%NRV
Fish oil850 mg
Omega 3, of which:637.5 mg
     -  EPA (Eicosapentaenoic Acid)425 mg
    - DHA (Docosahexaenoic Acid)170 mg
Vitamin E (D-alpha-tocopherol)3.35 mg27,9%
Red Yeast Rice (Monascus purpureus)58 mg
Total Monacolins, of which:2.9 mg
     - Monacolina K2.69 mg
Coenzyme Q1050 mg
Extract of sugar cane (Saccharum officinarum L), of which:10.20 mg
    -  Policosanol10 mg
    -  Octacosanol1.02 mg
Vitamin B6 (pyridoxal 5'-phosphate)0.7 mg50%
Vitamin B9 Quatrefolic® (5-methyltetrahydrofolate)200 μg100%
Vitamin B12 (methylcobalamin)1.25 μg50%

NRV: Nutrient Reference Value.
*%NRV not defined.

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