Vitamin B9, also called folate, is one of the water-soluble B vitamins.
Its name comes from the word “folia” which means leaf in Latin, due to its natural presence in green leafy vegetables.
Also in beans, wheat germ and yeast.
Other sources include egg yolk, milk and dairy, beetroot, orange juice, and wholemeal bread.
Vitamin B9 is given in different forms: the natural one which is folate and folic acid, which is a synthetic folate compound used in vitamin supplements and fortified foods because it is more stable. Folic acid contributes:
- to normal psychological function.
- Helps to reduce tiredness and fatigue.
- to the growth of maternal tissues during pregnancy.
- to normal amino acid synthesis.
- to the normal formation of blood cells.
- to normal homocysteine metabolism.
- to the normal functioning of the immune system.
- to the process of cell division.
Tiredness and fatigue associated with stress can be a causative factor in hair loss.
In food supplements, folate is usually found in the form of folic acid, but different salts such as 5-MTHF (methylfolate) can also be used.
Quatrefolic® glucosamine salt (6S)-5-methyltetrahydrofolate (5-MTHF).
The source of folic that is selected is very important.
Dietary supplements containing 5-MTHF may be better than folic acid for some people who have a gene mutation called MTHFR C677T because their bodies can use this form more easily.
This is because the body cannot transform the synthetic folic or folic present in fruits and vegetables into its methylated active form.
That is why our formulas contain Quatrefolic® (5-MTHF).
Quatrefolic® is a fourth-generation folate.
It is a registered trademark of Vitamin B9, (also known as Folate).
It is the glucosamine salt of (6S)-5-methyltetrahydrofolate (5-MTHF) and is structurally identical to the reduced, active form of folate found in our bodies. It is an innovative dietary ingredient that provides greater stability, improved bioavailability, higher water solubility, and flexibility for multi-ingredient formulations compared to a third-generation 5-MTHF calcium salt. In recent years, more and more evidence has been found of the advantages of reduced folate over folic acid.
The use of reduced folate (particularly reduced and methylated as Quatrefolic®) is the solution since a large part of the world’s population cannot assimilate and metabolize folic acid from foods or food supplements.
Quatrefolic® is manufactured under controlled conditions according to cGMP and since glucosamine does not come from animals or shellfish, Quatrefolic ® is a great choice for vegetarians.
In addition, Quatrefolic® is considered safe and is recognized as GRAS.
1. Patanwala I et al. Folic acid handling by the human gut: implications for food fortification and supplementation. Am J Clin Nutr. 2014
2. Scaglione F, Panzavolta G. Folate, folic acid and 5-methyltetrahydrofolate are not the same thing. Xenobiotica. 2014
3. Ulrich CM, Potter JD. Folate supplementation: too much of a good thing? Cancer Epidemiol Biomarkers Prev. 2006
4. Pietrzik K et al. Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics. Clin Pharmacokinet. 2010
5. Lawrence, Kripalani et al. « Profiling National Mandatory Folic Acid Fortification Policy Around the World. » New York: Springer; 2012
6. Ulric et al. « Folate Supplementation: Too Much of a Good Thing? » Cancer Epidemiol Biomarkers Prev 2006;15:189-193
7. Strum et al. « Enzymatic reduction and methylation of folate following pH-dependant, carrier-mediated transport in rat jejunum. » Biochim Biophys Acta 1979; 554, 249-257
8. Kelly et al. « Unmetabolized folic acid in serum: acute studies in subjects consuming fortified food and supplements. » Am J Clin Nutr 1997:65:1790-5
9. Jamil K. Clinical Implications of MTHFR Gene Polymorphism in Various Diseases. Biol Med. 2014
10. Wilcken B et al. Geographical and ethnic variation of the 677C>T allele of 5,10 methylenetetrahydrofolate reductase (MTHFR): findings from over 7000 newborns from 16 areas worldwide. J Med Genet. 2003
11. Seremak-Mrozikiewicz A et al. The significance of 1793G>A polymorphism in MTHFR gene in women with first trimester recurrent miscarriages. Neuro Endocrinol Lett. 2010
12. Tsang BL et al. Assessing the association between the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism and blood folate concentrations: A systematic review and meta-analysis of trials and observational studies. Am. J. Clin. Nutr. 2015
13. Sweeney MR et al. Persistent circulating unmetabolized folic acid in a setting of liberal voluntary folic acid fortification. Implications for further mandatory fortification? BMC Public Health. 2009
14. Smith AD. Folic acid fortification: the good, the bad, and the puzzle of vitamin B-12. Am J Clin Nutr. 2007
15. Smith D. A. et al. Is folic acid good for everyone? Am J Clin Nutr. 2008
16. Colman, Green, Metz et al. « Prevention of folate deficiency by food fortification. Il. Absorption of folic acid from staple foods. » Am J Clin Nutr I 975; 28:459-64
17. Shils et al. « Modern Nutrition in Health and Disease, 9th ed ». Williams & Wilkins, Balt., 1999
18. http://www.efsa.europa.eu/it/home/publication/efsafolicacid.pdf
19. Morris MS et al. « Circulating unmetabolized folic acid and 5-methyltetrahydrofolate in relation to anemia, macrocytosis, and cognitive test performance in American seniors ». Am J Clin Nutr. 2010