{"id":5225,"date":"2023-07-17T00:00:00","date_gmt":"2023-07-17T00:00:00","guid":{"rendered":"https:\/\/salengei.com\/active-revive-celular-the-anti-aging-revolution\/"},"modified":"2023-07-17T00:00:00","modified_gmt":"2023-07-17T00:00:00","slug":"active-revive-celular-the-anti-aging-revolution","status":"publish","type":"post","link":"https:\/\/salengei.com\/en\/blog\/active-revive-celular-the-anti-aging-revolution\/","title":{"rendered":"Active Revive Celular, the anti-aging revolution"},"content":{"rendered":"

From Salengei, we are very excited to present a product from the Active Supplements line that we have recently launched and of which we are extremely proud.
\nIt’s Active Revive Cellular<\/strong>, which is everything we’ve ever wanted to put at your fingertips in a single supplement. <\/p>\n

\n\t <\/h2>\n

Introduction to Aging<\/h2>\n

It is well known that the fight against the negative effects of ageing is increasingly becoming the focus of attention of scientists and researchers<\/strong>.
\nNot only for the simple fact of extending life expectancy, but also to counteract diseases associated with aging. <\/p>\n

There are several pages that we have dedicated to this topic in our blog and we will continue to do so, because each scientific advance that adds new expectations, not only encourages us, but challenges us to try it in order to offer it through our products.<\/p>\n

If you want to remember some of the most well-known theories of aging, click here<\/a> to redirect you to an article where we commented on it.<\/p>\n

Lifestyle changes can improve people’s health, but they alone are not enough to prevent diseases of old age.
\nAmong the strategies that have been used are repurposing existing drugs for geroprotection<\/strong>, which provide an additional weapon in the prevention of age-related deterioration, but as they are drugs, adverse effects always appear. <\/p>\n<\/p>\n

What affects the most<\/h2>\n

In one of the online meetings we had with our network of doctors, we commented that there are two phenomena that apparently share the most well-known theories of aging; immunoaging<\/em> and inflammaging<\/em><\/strong>. <\/p>\n

Human aging can be explained by the emerging concept of a combination of topics that are currently very much on the rise, which are the combination of immune senescence, inflammation, and aging.
\nThe inflammaging<\/em><\/strong> theory posits that aging, whether physiological or pathological, can be driven by cytokines and pro-inflammatory substances<\/strong> produced by the innate immune system.
\nThe concept of inflammation is based on a theory of programmed antagonistic pleitropy during evolution. https:\/\/doi.org\/10.2492\/inflammregen.29.249<\/a><\/p>\n

When we analyze immunaging<\/em><\/strong>, we would be focusing on the progressive filling of the immune system by activated lymphocytes, macrophages and dendritic cells in response to chronic diseases and subtle stress on an ongoing basis.<\/strong> This stress can be pathological or due to physiological antigens\/toxins.
\nThus, the condition of inflammation provides a mild and continuous antigenic action that leads to a pro-inflammatory condition associated with the progressive stimulation\/exhaustion of the immune system and other systems of the body. <\/p>\n

In general, immunosenescence can be taken as proof that the beneficial effects of the immune system, dedicated to the neutralization of dangerous and harmful agents that appear early in life, and that serve to improve the development and maturation tending to the prosperity of future generations and species in adulthood, they become harmful late in life.
\nThis is happening within a framework that would cover a period largely unforeseen by evolution. https:\/\/doi.org\/10.1111\/j.1749-6632.2000.tb06651.x<\/a><\/p>\n<\/p>\n

The most studied patterns or seals about aging<\/h2>\n

Human aging consists of an evolved mechanism of multiple hallmarks or patterns.
\nThis multi-layered view sheds light on the overall deleterious process.
\nThese stamps are cited below: <\/p>\n

    \n
  1. \n\t\tGenetic instability<\/strong>: DNA deterioration impacts cellular and mitochondrial functioning.
    \nThere is evidence that upregulating the mechanisms of repair of the same prolongs survival. <\/li>\n
  2. \n\t\tTelomere shortening<\/strong>: aging causes the ends of chromosomes to shorten, marking an older cell behavior, with fewer divisions and regeneration of tissues, and consequently more diseases.\"\"<\/li>\n
  3. \n\t\tEpigenetic alterations<\/strong>: the assembly instructions that come in our genome do not determine our health completely.
    \nThere are many mechanisms that allow us to interpret our guidelines in a better or worse way, facilitating or hindering the appearance of diseases to which we were predisposed. <\/li>\n
  4. \n\t\tLoss of proteostasis<\/strong>: the proteins in our body are in a constant cycle of creation, deterioration and elimination.
    \nThe loss of this balance produces an accumulation of protein waste in numerous organs, damaging their function. <\/li>\n
  5. \n\t\tDysregulation of nutrient sensitivity<\/strong>: over the years our body reacts less well to nutrients, producing resistance to insulin and other hormonal axes.
    \nCalorie restriction or its simulation with drugs has been shown to increase longevity; Hormone replacement also combats the effects of aging on target tissues. <\/li>\n
  6. \n\t\tMitochondrial dysfunction<\/strong>: mitochondria are the powerhouses from which we obtain energy through nutrients.
    \nIts dysfunction uncontrols oxidative stress and accelerates aging. <\/li>\n
  7. \n\t\tCellular senescence<\/strong>: when apoptosis is altered, tissues accumulate aged and poorly functional cells, and in the long term it is the tissue\/organ itself that stops functioning properly.<\/li>\n
  8. \n\t\tStem cell depletion<\/strong>: The reparative mechanisms of stem cells ensure greater survival and ability to reproduce.
    \nThe exhaustion of this capacity means that we are not able to regenerate properly after a certain age. <\/li>\n
  9. \n\t\tAlteration of intercellular communication<\/strong>: the alteration of hormonal systems, inflammation and the loss of blood-stimulating factors cause aging to go beyond a specific cell and become contagious.<\/li>\n<\/ol>\n

    \n

    \n

    How can we intervene in the different hallmarks of aging?<\/h2>\n

    Cells have different sets of molecules to perform a number of physiological functions. Nucleic acids have stored and transported information throughout evolution<\/strong>, while proteins have been credited with performing most cellular functions. <\/p>\n

    These attributes are achieved by a highly coordinated protein quality control (PQC) system comprising chaperones to fold proteins into a suitable three-dimensional structure, a ubiquitin-proteasome system for selective protein degradation, and autophagy for mass removal of cellular debris. <\/p>\n

    Many disturbances can lead to the weakening of the protective cellular machinery, leading to the deployment and aggregation of cellular proteins and the appearance of numerous pathological conditions.
    \nHowever, modulation of the expression and functional efficiency of molecular chaperones, E3 ubiquitin ligases and autophagic proteins can decrease the cellular proteotoxic load and mitigate several pathological effects. <\/p>\n

    Natural medicine and small molecule-based therapies have been well documented for their effectiveness in modulating these pathways and restoring lost proteostasis within cells to fight disease. https:\/\/doi.org\/10.3389\/fgene.2021.693071<\/a><\/p>\n<\/p>\n

    The Achievement: Active Revive Cellular<\/h2>\n

    By documenting all the processes detailed above, we have tried to come together in a product that adds active ingredients that act directly on all the layers associated with aging<\/strong>.
    \nBelow, we leave a list of the main components of Active Revive Cellular.<\/strong> <\/p>\n