{"id":5221,"date":"2023-01-20T00:00:00","date_gmt":"2023-01-20T00:00:00","guid":{"rendered":"https:\/\/salengei.com\/active-procollagen-plus-for-bones-and-joints\/"},"modified":"2023-01-20T00:00:00","modified_gmt":"2023-01-20T00:00:00","slug":"active-procollagen-plus-for-bones-and-joints","status":"publish","type":"post","link":"https:\/\/salengei.com\/en\/blog\/active-procollagen-plus-for-bones-and-joints\/","title":{"rendered":"ACTIVE PROCOLLAGEN PLUS for bones and joints"},"content":{"rendered":"

As age advances, different conditions begin to show in the bones and joints.
\nIf these negative changes progress, they lead to the appearance of osteoporosis, osteoarthritis and osteoarthritis.
\nTherefore, it is important to detect it early and apply measures that contribute to slowing down the advance of the problem.
\nToday’s topic is hydrolyzed collagen and the different benefit options offered by its consumption.<\/strong> <\/p>\n<\/p>\n

\n\tTalking about bones<\/strong><\/h1>\n

Bone is made up of several tissues, the main one being bone tissue.
\nThe inorganic matrix<\/strong> provides hardness and among its main components we find minerals such as calcium and magnesium.
\nWithin the organic matrix of bone, 94% is composed of collagen<\/strong>.
\nThe aforementioned minerals adhere to this collagen structure.
\nWithout this support structure, the bone lacks solidity. <\/p>\n

On the other hand, osteoporosis is a chronic and asymptomatic disease characterized by low bone mass, deterioration of skeletal microarchitecture, increased risk of fracture<\/strong> and associated comorbidities, being more prevalent in the elderly.
\nDue to the increasing aging of the population, osteoporosis has become a major health problem that requires innovative treatment of the disease. <\/p>\n<\/p>\n

\n\tThe facts<\/strong><\/h1>\n

A study was designed with the aim of investigating the effect of hydrolyzed collagen on bone metabolism, especially in the perspective of the treatment of osteoporosis.
\nIt was carried out in vivo in female mice that were ovariectomized or simulated oophorectomy.
\nThe study subjects were 12 weeks old and they were fed for 12 weeks on a diet containing 10 or 25 g\/kg of hydrolyzed collagen. <\/p>\n

Bone mineral density for mice fed the hydrolyzed collagen diet was significantly higher compared to control mice.
\nThe blood level of C-terminal telopeptide of type I collagen, a marker of bone resorption, and alkaline phosphatase decreased significantly when mice were fed either diet containing hydrolyzed collagen.
\nFinally, a significant increase in bone strength correlated with geometric changes was demonstrated for ovariectomized mice.
\nDOI: 10.1016\/j.bone.2009.10.035<\/a> <\/p>\n

\n

\n\t\tCollagen can contribute to improving bone density<\/span><\/h4>\n<\/blockquote>\n

Orally administered collagen can be digested in the gut, cross the intestinal barrier and enter the circulation, and become available for metabolic processes in target tissues.
\nIn this way, it can be speculated that a diet enriched with collagen provides benefits for bones and joints in the human body.
\nIn addition, collagen-derived products such as gelatin or hydrolyzed collagen are recognized for their nutritional safety. <\/p>\n

In another systematic review of scientific literature, the aim was to demonstrate the antiosteoporotic and antiarthrosis effects of hydrolyzed collagen.
\nThe conclusion was that daily doses equivalent to 12g of hydrolyzed collagen have a positive therapeutic effect on osteoporosis and osteoarthritis with a potential increase in bone mineral density, a protective effect on joint cartilage, and especially in symptomatic pain relief. https:\/\/doi.org\/10.1590\/1809-9823.2016.14145<\/a><\/p>\n

In addition, combined oral administration of hydrolyzed collagen with calcium and vitamin D has been reported to have better effects on bone health than solitary administration of the elements.
\nDOI: 10.1371\/journal.pone.0135019<\/a> <\/p>\n<\/p>\n

\n\tDoes it only work on osteoporosis and osteoarthritis?<\/strong><\/h1>\n

As you well know, at Salengei<\/strong> we never stop at just one approach.
\nThat is why we have continued to investigate and below, we present a list of different beneficial effects of hydrolyzed collagen and their supporting scientific correlate. <\/p>\n

\"\"<\/p>\n

\n\tImproved antioxidant capacity<\/strong><\/h2>\n

Hydrolyzed collagen has good antioxidant activity <\/strong>as demonstrated by in vitro<\/em> tests (DOI:10.1016\/j.foodchem.2010.08.058<\/a>).
\nIntake of hydrolyzed collagen also increases the activities of antioxidant enzymes in the body, including superoxide dismutase, glutathione-peroxidase, and catalase (DOI: 10.1002\/jsfa.8098<\/a>) <\/p>\n<\/p>\n

\n\tAnti-aging effect<\/strong><\/h2>\n

The anti-aging effect of collagen has been extensively researched in several animal models.
\nBeneficial effects have generally been seen, including increased skin hydration, decreased formation of deep wrinkles, and improved skin elasticity<\/strong> after taking 10 g of hydrolyzed collagen once daily for more than 6 weeks (DOI: 10.2174\/1876396001508010029<\/a>).
\nIt should be noted that the effect of hydrolyzed collagen against aging is most evident in women over 30 years of age.
\nThe mechanisms underlying the beneficial effects may be involved in the dual effects on the synthesis and degradation of skin collagen. <\/p>\n<\/p>\n

\n\tImproves wound healing<\/strong><\/h2>\n

Oral administration of marine hydrolyzed collagen has been reported to improve skin wound healing and angiogenesis<\/strong> in rats.
\n(DOI: 10.1002\/jsfa.4435<\/a>).
\nIn addition to the elevated expression of Vascular Endothelial Growth Factor and Fibroblastic Growth Factor-2, the effect of hydrolyzed collagen on the fibroblast may be one of the mechanisms underlying the improvement in wound healing, as a previous study reported that Proline-Hydroxyproline, a collagen-derived dipeptide, exerts a chemotactic action on fibroblasts and stimulates their proliferation. <\/p>\n<\/p>\n

\n\tAnti-inflammatory effect<\/strong><\/h2>\n

Glycine is one of the main structural units of collagen, accounting for one-third of amino acids. Hydrolyzed collagen has the ability to reduce inflammatory responses<\/strong>.
\n(DOI: 10.3177\/jnsv.56.208<\/a>).
\nThis effect may be due to inhibition of the production of pro-inflammatory cytokines through glycine-gated chloride channels (GlyR). <\/p>\n<\/p>\n

\n\tReduces the risk of cardiovascular disease<\/strong><\/h2>\n

The antihypertensive effect of hydrolyzed collagen has been reported in experimental animals and clinical trials (DOI: 10.1271\/bbb.120718<\/a>).
\nOral administration of collagen-derived Glycine-Leucine-Proline significantly decreases systolic tension by inhibiting angiotensin-converting enzyme I (ACE).
\nAnother study found that oral administration of collagen tripeptide had an inhibitory effect on the development of atherosclerosis in hypercholesterolemic rabbits (DOI: 10.1016\/j.jbiosc.2014.10.011<\/a>).
\nIt is known that platelets are involved in the pathophysiology of atherosclerosis and thrombosis.
\nIn this case, hydrolyzed collagen has inhibitory activity on platelet release and aggregation<\/strong>, which may justify the potential application of this supplement to prevent and\/or treat atherosclerosis and thrombosis. https:\/\/doi.org\/10.1111\/jcmm.13317<\/a> <\/p>\n<\/p>\n

\n\tACTIVE PROCOLLAGEN PLUS<\/strong><\/h1>\n

One of our star products is Active Procollagen Plus<\/a><\/strong> , which contains Peptan\u00aeF 5000LD, a high-purity hydrolyzed type I collagen with a protein content of more than 97%. Active Procollagen Plus<\/a><\/strong> is a powdered supplement that contains a high concentration of type I collagen peptides from fish, the same collagen found in bones and skin.
\nPeptan\u00ae collagen has a low density molecular weight (5000 Da), and thanks to this, it provides excellent solubility and absorption. <\/p>\n

In addition, another component is calcium<\/strong>, which is provided by Lithothamnium calcareum<\/strong>, an algae that belongs to the group of marine red algae of the Coralineceae family.
\nThey develop at great depths and during their growth stage they absorb nutrients and minerals from the sea.
\nAlgae contain 10 to 15 times more trace elements than their terrestrial counterparts. <\/p>\n

Vitamin C<\/strong>, another component of our Active Procollagen Plus<\/a>, <\/strong>is key in the formation of collagen, as we have discussed in detail in other posts.
\nOur product contains 500mg, which provides several times more than the daily nutritional requirements. <\/p>\n

Other components are the
\nmagnesium, glucosamine, methylsufonylmethane<\/strong> (an organic form of sulfur that helps strengthen connective tissue); the
\nellagic acid<\/strong> (derived from pomegranate, with powerful antioxidant action),
\nhyaluronic acid<\/strong> that provides hydration to the skin and joints; the
\nbamboo extract<\/strong>, which provides organic silicon, one of those components of inorganic matter that provides hardness to the bone, as well as nails, and hair; hesperidin, vitamin D3<\/strong> that is necessary for calcium to be absorbed at the intestinal level and vitamin<\/strong> K2<\/strong> necessary for calcium to crystallize in the bone and not in the arteries and various trace elements and amino acids such as L-arginine, L-lysine<\/strong> very useful for its synergistic action. <\/p>\n

\"\"<\/p>\n

We have recently improved the formula of Active Procollagen Plus<\/a>.
\nIn particular, we have reduced the magnesium content from 400 mg to 300 mg (an optimal and sufficient daily intake) and replaced the sweetener sucralose with steviol glycosides for better tolerance.
\nThe rest of the ingredients that make up the product are maintained, so we continue to offer you a high-quality product. <\/p>\n

\n\t <\/h1>\n

\n\tConclusion<\/strong><\/h1>\n

Until some time ago, hydrolyzed collagen was only ingested for aesthetic purposes, due to its proven effectiveness in reducing wrinkles and strengthening the collagen matrix visible in the skin.
\nBut after countless investigations, it has been shown that these effects are just a few of others with deeper organic bases and that they have a positive impact on physiological functions.
\nThat is why incorporating a dose of 11 grams of Active Procollagen Plus<\/a> <\/strong>into daily meals promotes overall health. <\/p>\n","protected":false},"excerpt":{"rendered":"

As age advances, different conditions begin to show in the bones and joints.
\nIf these negative changes progress, they lead to the appearance of osteoporosis, osteoarthritis and osteoarthritis.
\nIn today’s post we talk about collagen and its benefits in preventing this problem. <\/p>\n","protected":false},"author":3,"featured_media":2688,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-5221","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"\nACTIVE PROCOLLAGEN PLUS for bones and joints - Salengei<\/title>\n<meta name=\"description\" content=\"As age advances, different conditions begin to show in the bones and joints. If these negative changes progress, they lead to the appearance of osteoporosis, osteoarthritis and osteoarthritis. 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