{"id":5212,"date":"2023-01-30T00:00:00","date_gmt":"2023-01-30T00:00:00","guid":{"rendered":"https:\/\/salengei.com\/importance-of-detox-before-a-weight-loss-diet\/"},"modified":"2023-01-30T00:00:00","modified_gmt":"2023-01-30T00:00:00","slug":"importance-of-detox-before-a-weight-loss-diet","status":"publish","type":"post","link":"https:\/\/salengei.com\/en\/blog\/importance-of-detox-before-a-weight-loss-diet\/","title":{"rendered":"Importance of detox before a weight loss diet"},"content":{"rendered":"

After the holidays, and at the end of January, our body asks us for a complete reset, a detox to start the year off right.
\nCelebratory meals are usually loaded with fats, sugars, additives, and tremendous amounts of calories that can affect the normal functioning of our body. <\/p>\n

That is why before starting a weight loss or healthy eating diet, it is necessary to “empty our body of toxins”, so that everything can flow correctly.<\/p>\n

Detox for our greatest purifying organ<\/h2>\n

Detox diets are interventional strategies that aim to facilitate the elimination of toxins and weight loss<\/strong>, thereby promoting health and well-being.
\nPreviously, in another post<\/a> on our blog we talked about the different stages or stages of the internal detox process in our body. <\/p>\n

The liver is a vital organ involved in a host of functions, including the production of plasma and bile proteins, the metabolism of carbohydrates, lipids, and amino acids, and the synthesis of urea.
\nIn addition, this organ is primarily responsible for the detoxification of xenobiotics, including drugs and toxic endogenous compounds<\/strong>.
\nThe detoxification process, also known as xenobiotic metabolism, involves at least two phases with different reactions: in phase I of the internal detox process, toxic products are transformed into intermediate forms more accessible for phase II.
\nThese intermediate forms are much more chemically active and therefore more toxic. <\/p>\n

The chemical reactions involved in the metabolism of drugs and other toxins usually convert these substances into more water-soluble metabolites<\/strong>, which facilitates their eventual excretion in urine and feces.<\/p>\n

\"\"<\/p>\n

Glutathione reductase is a flavoprotein that catalyzes the NADPH-dependent reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH).
\nThe reaction is essential for the maintenance of glutathione levels.
\nGlutathione has a major role as a reducer in oxidation-reduction processes and serves in detoxification and other important cellular functions.
\nReduced glutathione will be used by glutathione peroxidase for the reduction of peroxide and lipoperoxides, which are reactive oxygen species.
\nThis enzyme plays an important role in antioxidant defense<\/strong> and its presence is highly widespread in different tissues and organs. https:\/\/doi.org\/10.1016\/S0076-6879(85)13062-4<\/a> <\/p>\n<\/p>\n

Some common drugs can be harmful<\/h2>\n

Paracetamol hepatotoxicity, for example, is the leading cause of drug-induced liver failure<\/strong>.
\nAlthough some of the mechanisms of acetaminophen-induced liver cell injury are not yet fully understood, some studies suggest that the formation of reactive metabolites, glutathione depletion, and alkylation of proteins, especially mitochondrial proteins, are critical initiating events for toxicity.
\nMembers of the Bcl-2 family, Bax and Bid, form pores in the outer mitochondrial membrane and release intermembrane proteins, e.g., apoptosis-inducing factor and endonuclease G, which then move into the nucleus and initiate chromatin condensation and DNA fragmentation, respectively.
\nMitochondrial dysfunction, due to covalent binding, leads to the formation of reactive oxygen and peroxynitrite, which trigger the transition of membrane permeability and the collapse of mitochondrial membrane potential.
\nIn addition to the decreased ability to synthesize ATP, more endonuclease G and AIF are released.
\nEndonuclease G, together with an activated nuclear Ca2+-dependent endonuclease, Mg2+, cause DNA degradation, which prevents cell recovery and regeneration<\/strong>.
\nDOI: 10.1093\/toxsci\/kfi336<\/a> <\/p>\n

It is at this time that our body will benefit from the use of Active detox<\/strong><\/a>, <\/strong> a supplement specially designed to provide the components that are needed to achieve a good result in our detox process.
\nBelow, we will briefly outline some of its most important assets: <\/p>\n