{"id":5207,"date":"2022-10-27T00:00:00","date_gmt":"2022-10-27T00:00:00","guid":{"rendered":"https:\/\/salengei.com\/products-to-delay-aging\/"},"modified":"2022-10-27T00:00:00","modified_gmt":"2022-10-27T00:00:00","slug":"products-to-delay-aging","status":"publish","type":"post","link":"https:\/\/salengei.com\/en\/blog\/products-to-delay-aging\/","title":{"rendered":"Products to delay aging"},"content":{"rendered":"

In June 2018, the World Health Organization (WHO) published the eleventh edition of its International Classification of Diseases and, for the first time, added aging. <\/p>\n

The classification of aging as a disease paves the way for new research into novel therapies to delay or reverse age-related diseases, such as cancer, cardiovascular and metabolic diseases, and neurodegeneration.<\/p>\n

\n

\n\t\tWe are in the new era where advances in science lead us to ingredients focused on cell regeneration or those that protect or prevent cell damage<\/strong><\/h4>\n<\/blockquote>\n

If we know what the biological bases of a process are and how it is dysregulated in the disease, we can try to act to reverse or shape it.<\/p>\n<\/p>\n

\n\tAging<\/strong><\/h1>\n

Aging is marked by epigenetic changes, genomic instability, impaired ability to detect nutrients, telomere wear, mitochondrial dysfunction, cellular senescence, stem cell depletion, dysregulated intercellular communication, and cellular oxidation.<\/p>\n

Today we already have some active ingredients that can target these processes.<\/p>\n

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\n\t\tAging is the set of changes that accumulate over time due to the increasing production of damaged proteins.<\/strong><\/h4>\n<\/blockquote>\n

When a protein is oxidized<\/strong>, it is already damaged and it is difficult to reverse the process, so it is destroyed, it can also happen that the ability of proteins to maintain their shape and stability is lost, since if they are damaged they lose their structure and are not properly folded.
\nThat is why we need chaperones, which are like structures or protective shields that protect proteins from degradation.
\nOur body has the capacity to produce about 100 chaperones. <\/p>\n

If we are able to protect the protein from damage, it protects against the effects of aging and protects us from all the stress related to the damage that occurs in the body.<\/p>\n

To minimize protein damage, it is necessary to reduce oxidation and protect them with these protective shields.<\/p>\n

Oxidation can be caused by the body itself, or by external factors such as UV radiation, pollution, tobacco smoke, pesticides, etc. <\/p>\n

\"\"<\/p>\n<\/p>\n

\n\tAnti-aging food supplements <\/strong><\/h1>\n

\n\tChronoshield<\/strong><\/h2>\n

Chronoshield is the only product on the market that has proven to be effective in protecting proteins from oxidation, degradation, so it can help maintain their shape, thanks to its chaperone effect mechanism.<\/p>\n

It protects proteins from external damage or stress caused by various environmental agents.
\nWe remember the post: How to protect our proteins to stop the aging process<\/a>. <\/p>\n<\/p>\n

\n\tSenolytic Platinum<\/strong><\/h2>\n

Another way of acting would be to eliminate senescent cells from the body and stimulate the creation of new healthy cells.
\nThis function is performed by Senolytics.
\nThat is why we also want to tell you about Senolytic Platinum <\/p>\n

First of all, let’s remember that the lifespan of all cells is limited.
\nThus, a cell that reaches the end of its life proceeds to self-destruct, so as not to saturate the body.
\nThis natural process is called apoptosis. <\/p>\n

Sometimes, cells at the end of their life do not enter the phase of cell death.
\nThese cells, called senescent cells, continue to wander through the body.
\nAt first, our immune defenses manage to eliminate them, but very quickly, senescent cells end up accumulating and overwhelming the immune system, which becomes unable to get rid of them. <\/p>\n

Sometimes the worst happens, instead of dying, in an attempt to survive, they mutate and become cancerous.<\/p>\n

Essentially, senescence and carcinogenesis (oncogenesis) direct cellular fate in opposite directions.<\/p>\n

Today we have Senolytic Platinum, a patented product that provides Fisetin <\/strong>, one of the most powerful senolytic flavonoids.<\/p>\n

Other well-known senolytics are quercetin and<\/strong> the caloric restriction mimetic, resveratrol<\/span><\/a> , which aims to slow down the aging process.
\nThe antioxidant effects of these flavonoids and in particular the induction of glutathione synthesis are considered important with regard to neuroprotection and other anti-aging effects. <\/p>\n

Grynkiewicz G, Demchuk OM.
\nNew Perspectives for Fisetin.
\nFront Chem.
\n2019 Oct 30;7:697.
\nDOI: 10.3389\/FCHEM.2019.00697.
\nPMID: 3175028. <\/h6>\n<\/p>\n

\n\tResveratrol<\/strong><\/h2>\n

<\/strong>Resveratrol<\/span><\/a>, a polyphenol already well studied, is not new in the anti-aging repertoire.
\nResearch on this ingredient began through the “French paradox,” which described better cardiovascular outcomes in the French despite a high-fat diet because they drank more wine.
\nSince then, it has been shown to have antioxidant, anti-inflammatory, antiproliferative, and anti-angiogenic effects. <\/p>\n

The benefits of resveratrol<\/span><\/a> are multiple, so we want to remember a post where we talked extensively about the subject: Therapeutic effects of resveratrol<\/a><\/p>\n

\"\"<\/p>\n<\/p>\n

\n\tSpermidine<\/strong><\/h2>\n

It is a polyamine (biogenic amine) that induces autophagy, a process that eliminates defective cells from our body.<\/p>\n

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\n\t\tSpermidine is another of these novel active ingredients<\/strong><\/h4>\n<\/blockquote>\n

The name spermidine curiously comes from semen, since it is where it was first isolated, it was the scientist Von Leeuwenhoek, father of microscopy, in 1678, who informed the Royal Society that part of his sperm samples had crystallized.
\nMuch later, in the 1920s, these crystals were called spermine and their reason was to protect the DNA of semen. <\/p>\n

When we are young and growing, we have higher spermidine levels than when we age.
\nThis decrease sometimes manifests itself in the form of loss of muscle mass, hair loss, sagging skin, and wrinkles. <\/p>\n

We can ingest spermidine from food sources and either synthesize it through the gut microbiota.<\/p>\n

Spermidine activates autophagy, a process that removes defective cells from our body.
\nThis could play a role in protecting against cancer. <\/p>\n

Spermidine has been attributed with effects such as preserving cognitive function, anti-inflammatory effects, antifibrotic effect on the liver, improvement of IBD (inflammatory bowel disease), colitis, inhibition of aberrant DNA methylation among other effects.<\/p>\n

\n

\n\t\tAnother way of acting can be against telomere shortening.
\nThis is a well-known theory related to aging. <\/strong><\/h4>\n<\/blockquote>\n

Telomeres are regions of DNA, located at the ends of chromosomes. Their main function is to protect the cell when it multiplies and divides.
\nWhen a cell duplicates, so does its genetic material.
\nHowever, this multiplication, which should be identical, really isn’t, since telomeres are shortened in the process. <\/p>\n

It is a gradual shortening that begins from the very moment we are born until we die.<\/p>\n

As a consequence of the problem of cell replication, telomeres shrink in each cell generation until they reach a minimum length in the crisis phase of aging, the speed of division is reduced, determining a slow cell death.
\nThis phenomenon is called “replicative mortality”. <\/p>\n

Cells involved in growth, development and reproduction (stem cells, eggs and sperm) unlike somatic cells synthesize large amounts of the enzyme telomerase<\/strong>, an enzyme involved in preserving the length of telomeric DNA<\/strong> contrary to what most adult cells do that express little or none of this enzyme. which causes these cells to age and eventually die.<\/p>\n

\n\tMeccariello, R.; D’Angelo, S. Impact of Polyphenolic-Food on Longevity: An Elixir of Life. <\/em>An Overview.
\nAntioxidants 2021, 10, 507. https:\/\/doi.org\/10.3390\/antiox10040507<\/a><\/em><\/h6>\n

An interesting product is TA65<\/a>, whose patented active ingredient<\/strong> extracted from Astragalus membranaceus<\/em><\/strong>, has the ability to activate telomerase and repair critically short telomeres, something so essential to keep our cells alive, longer.<\/p>\n

\n\tBernardes de Jesus B, Schneeberger K, Vera E, Tejera A, Harley CB, Blasco MA. <\/em>The telomerase activator TA-65 elongates short telomeres and increases health span of adult\/old mice without increasing cancer incidence.
\nAging Cell.
\n2011 Aug; 10(4):604-21.
\ndoi: 10.1111\/j.1474-9726.2011.00700.x.
\nEpub 2011 Apr 14.
\nPMID: 21426483. <\/em><\/h6>\n
\n\tSalvador L, Singaravelu G, Harley CB, Flom P, Suram A, Raffaele JM.
\nA Natural Product Telomerase Activator Lengthens Telomeres in Humans: A Randomized, Double Blind, and Placebo Controlled Study.
\nRejuvenation Res.
\n2016 Dec; 19(6):478-484.
\nDOI: 10.1089\/REJ.2015.1793.
\nEpub 2016 Mar 30.
\nPMID: 26950204; PMCID: PMC5178008. <\/em><\/h6>\n
\n

\n\t\tAnother interesting approach to slow down the aging process is to act on the mitochondria, the cellular energy factory<\/strong><\/h4>\n<\/blockquote>\n

In it we find very important tandems, molecules and cofactors that need each other to be able to manufacture final energy molecules or ATP, they are Coenzyme Q10<\/strong>, PQQ,<\/strong> NAD+<\/strong>, NMN<\/strong> and NADH.<\/strong><\/p>\n<\/p>\n

\n\tNMN, nicotinamide mononucleotide<\/strong><\/h2>\n<\/p>\n

\"\"<\/p>\n

This is another of the new anti-aging players.
\nBoth NMN and NAD+ are important producers of energy in the body.
\nAlthough they are different molecules, NAD+ and NMN have many chemical elements in common.
\nMost importantly, the body needs NMN to create NAD+ \u2013 you can’t have one without the other. <\/p>\n

There are a few differences between NAD and NMN:<\/p>\n