{"id":5190,"date":"2021-10-28T00:00:00","date_gmt":"2021-10-28T00:00:00","guid":{"rendered":"https:\/\/salengei.com\/stand-up-to-cystitis-with-cystiplus\/"},"modified":"2021-10-28T00:00:00","modified_gmt":"2021-10-28T00:00:00","slug":"stand-up-to-cystitis-with-cystiplus","status":"publish","type":"post","link":"https:\/\/salengei.com\/en\/blog\/stand-up-to-cystitis-with-cystiplus\/","title":{"rendered":"Stand up to cystitis with CystiPlus\u00ae"},"content":{"rendered":"

Bacteria can colonize the urinary tract and thus cause urinary tract infections.
\nThis factor is usually a recurring issue depending on the immune capacity of the person and even its virulence and intensity will depend.
\nIn this post we will talk about urinary tract infections and a new product available to Salengei, CystiPlus\u00ae<\/a>. <\/p>\n

CystiPlus\u00ae<\/a> contains 175mg of American cranberry<\/strong> extract (Vaccinum macrocarpon) per tablet.
\nIn addition, it has an 80% proanthocyanidin<\/strong> titration, which makes it, by far, a product of high purity and efficacy. <\/p>\n<\/p>\n

\n\tRevisiting history<\/strong><\/h1>\n

Blueberries have a rich history of medicinal uses and on both sides of the ocean.
\nMany of these uses, which were once thought to be anecdotal, are now the subject of intense scientific research, as their consumption has been clinically proven to prevent urinary tract infections. <\/strong> <\/p>\n

Until recently it was thought that the effect was due to the acidification of the urine, however, research suggests that the proanthocyanidin compounds present in this fruit act to inhibit bacterial adhesion to the uroepithelium<\/strong>, preventing colonization and infection of the urinary tract.<\/p>\n<\/p>\n

\n\tRemembering proanthocyanidins<\/strong><\/h1>\n

Flavonoids are a group of natural products with a wide spectrum of pharmacological properties that have received great attention in the scientific field.
Berries contain high amounts of polyphenols<\/strong>, including flavonoids.
\nThese fruits have gained great prominence lately and are widely consumed around the world mainly due to their healthy properties in a wide number of biological functions. <\/p>\n

Proanthocyanidins constitute the end product of the flavonoid biosynthesis pathway.
\nChemically they are converted to anthocyanins in the same way that polysaccharides are metabolized to simpler units of sugars.
\nIn chemical terms, anthocyanins are glycosides of anthocyanidins, that is, they are made up of an anthocyanidin molecule, which is agglycone, to which a sugar is attached by means of a \u03b2-glycosidic bond. <\/p>\n

There are currently more than 600 different anthocyanins<\/strong> described in the plant kingdom and the reported health effects are mainly related to their antioxidant and anti-inflammatory activity in the prevention of some metabolic disorders. https:\/\/doi.org\/10.1016\/j.jff.2013.05.010<\/a><\/p>\n

Among fruits, blueberries are one of the richest sources of anthocyanins<\/strong>, making them fruits of high interest in terms of bioactive potential.
\nAnthocyanins extracted from blueberries are widely known as adjuvants in the prevention or treatment of urinary tract infections. <\/p>\n

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Anthocyanins in blueberries contribute to the prevention and treatment of urinary tract infections<\/h4>\n<\/blockquote>\n

Flavonoids are thought to have evolved in plants to defend them from potentially deleterious ultraviolet radiation from the sun.
\nDue to their structures rich in hydroxyl groups, they easily bind to protein surfaces<\/strong>, becoming potent inhibitors of some enzyme systems. <\/p>\n

Within the broad group of flavonoids, anthocyanins and proanthocyanidins stand out.
\nAnthocyanins (from the Greek, anthos: flower and ky\u00e1neos: blue), are pigments that provide the red, blue and violet colors to plants.
\nProanthocyanidins are polymers made up of units of anthocyanidins. <\/p>\n

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\n\tAnthocyanins and bacteria <\/strong><\/h1>\n

After consumption, the anthocyanins present in blueberries are intensively metabolized mainly in the intestines and liver.
\nGlucuronization, methylation, and sulfation are the most typical metabolic reactions. <\/p>\n

In one study, proanthocyanidin-rich fractions were separated using vacuum and chromatography.
\nThe fractions were characterized using analytical tools that included two different types of spectrometry.
\nThere was a significant positive correlation between the proanthocyanidin content of different fractions and biological activity in both the antiproliferation and bacterial anti-adhesion assays. <\/p>\n

https:\/\/doi.org\/10.1021\/jf049238n<\/a><\/p>\n

In another study, the action of anthocyanins was measured on some Gram(-) antibiotics, such as gentamicin.
\nThe conclusion was that anthocyanin-rich extracts from the four blueberry varieties studied effectively inhibited all tested urinary tract infections<\/strong> and standard strains, with MIC (minimum inhibitory concentration) ranging from 0.4mg\/ml (for Pseudomona aeruginosa<\/em>) to 9.5mg\/ml (for Klebsiella pneumoniae<\/em>). <\/p>\n

The findings were surprisingly effective against Pseudomona aeruginosa<\/em> in UTI strains, demonstrating a potential new approach in the effort to find new measures to control some antibiotic-resistant UTI strains https:\/\/doi.org\/10.3390\/antiox9060478<\/a><\/p>\n<\/p>\n

\n\tCranberries<\/strong><\/h1>\n

Cranberry proanthocyanidins have been shown to inhibit the adhesion of P-fimbriated Escherichia coli<\/em> to uroepithelial cells<\/strong>, and this effect on virulence is dose-dependent.
\nBecause Escherichia coli<\/em> accounts for the majority of urinary isolations among nursing home residents, cranberry products remain an attractive UTI prevention strategy.
DOI: 10.1056\/NEJM199810083391516 <\/p>\n

Among the different bioactive substances in berries, phenolic compounds, including flavonoids, tannins, and phenolic acids, have received considerable interest for their effects on diet and health.
\nThere is a great deal of in vitro evidence showing that the phenolics in berries are powerful antioxidants.
\nHowever, the antioxidant effect of berry phenolics is highly dependent on the choice of berry raw material, as the antioxidant activity differs between different phenolic components, including anthocyanins, ellagitannins, and proanthocyanidins. <\/p>\n

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Cranberry contains Proanticyanidins with the ability to inhibit P-type fimbriae in antibiotic-sensitive and antibiotic-resistant E. coli<\/em> strains<\/h4>\n<\/blockquote>\n

In food, the antioxidant effect is also influenced by the structure of the food. Berries containing tannins exhibit antimicrobial properties against pathogenic bacteria<\/strong>, thus offering many new applications for the food industry.
\nMuch of the interest in berry phenolics has focused on blueberries, both cultivated and wild, although other berries, such as blackcurrants, blackberries and raspberries, also possess promising bioactivities that may have relevance to human health. https:\/\/doi.org\/10.1002\/mnfr.200700006<\/a><\/p>\n

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\n\t <\/h1>\n

\n\tD- Mannose<\/strong><\/h1>\n

The formula contains D-Mannose, a type of sugar present in human metabolism.<\/p>\n

Interestingly, the bacteria bind to the mannose molecules present in the uroepithelium and for this reason the infection process begins.
\nHowever, such binding can be competitively inhibited with excreted mannose. <\/p>\n

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D-mannose can promote the elimination of bacteria through urine<\/h4>\n<\/blockquote>\n

The consumption of Mannose will contribute to the binding of the pathogen to free mannose and the colonization of the uroepithelium will be inhibited.
\nIn addition, the binding to free mannose allows bacteria to remain in the urine, facilitating their elimination with urination. <\/p>\n

\n\t <\/h1>\n

\n\tThe juniper<\/strong><\/h1>\n

Traditional medicine attributes diuretic, antiseptic, carminative and stomach properties to juniper fruits.
\nThanks to its diuretic, antimicrobial and anti-inflammatory activity,<\/strong> it has been traditionally used for the treatment of urinary tract infections. The chemical composition of juniper essential oil includes about 105 constituents, among those present are monoterpenes (58% essential oil with a content of 20% in \u03b1-pinene, 8.7% in limonene, 8.5% in myrcene, among others), tannins (proanthocyanidins, gallocatechin and epigallocatechin) and flavonoids (quercetin, isoquercetin, apigenin and amentoflavone).<\/p>\n

Juniper has diuretic, antimicrobial and anti-inflammatory capacity that contributes to reducing urinary tract infections<\/h4>\n

Juniper is one of the components of CystiPlus\u00ae<\/a>, which would act synergistically with the proanthocinidins of blueberry, to prevent urinary tract infections.<\/p>\n<\/p>\n

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\n\tConclusion<\/strong><\/h1>\n

Many times we get a type of familiar or folkloric knowledge that we deny despite having empirical evidence that it really works.
\nThese are the so-called grandmother’s secrets.
\nNowadays, this non-academic knowledge has been valued and there is a tendency to contrast it through scientific methods with a view to validating (or refuting) its veracity. <\/p>\n

In the case of blueberries, much has been said about the beneficial effect of prevention and therapy on urinary tract infections.
\nAt Salengei<\/strong> we have opted for a product that M4Pharma had previously been distributing, CystiPlus\u00ae<\/a>.
\nThis supplement is indicated in cases of prevention of recurrent urinary tract infections. <\/p>\n

Cystiplus is a dietary supplement based on cranberry 140 mg PAC (proanthocyanidins), D-mannose, and juniper for urinary well-being.<\/p>\n

CystiPlus\u00ae<\/a> is a unique supplement with triple efficacy<\/strong>.
\nThese three components work synergistically to combat recurrent cystitis. <\/p>\n