{"id":5189,"date":"2021-12-27T00:00:00","date_gmt":"2021-12-27T00:00:00","guid":{"rendered":"https:\/\/salengei.com\/combat-dao-deficit-with-daosin\/"},"modified":"2021-12-27T00:00:00","modified_gmt":"2021-12-27T00:00:00","slug":"combat-dao-deficit-with-daosin","status":"publish","type":"post","link":"https:\/\/salengei.com\/en\/blog\/combat-dao-deficit-with-daosin\/","title":{"rendered":"Combat DAO Deficit with DAOSin"},"content":{"rendered":"

Before we start with our article this week, we want to wish you a very happy holiday season.
\nWe are not living in easy times, but we are faithful believers that together we will overcome this difficult time. <\/p>\n

That said, we proceed to present our article today with one of the most requested topics by you and that is DAO (DiAmino Oxidase) deficiency<\/strong>.
\nWe take advantage of the opportunity because during the holidays more foods with high histamine levels are consumed. <\/p>\n<\/p>\n

\n\tLet’s start from the beginning<\/strong><\/h1>\n

Histamine is a protein that belongs to the so-called biogenic amines and is present in many foods that we consume on a regular basis, as well as inside our cells.
\nThe intake of histamine through meals does not cause any type of alteration or problem, since it is processed and metabolized quickly by the DAO. <\/p>\n

DiAminoOxidase belongs to the group of amino oxidase enzymes that contain copper.
\nThese enzymes deaminate primary amines into the corresponding aldehydes, ammonia, and hydrogen peroxide through oxidation.
\nHuman DAO preferentially degrades histamine and various polyamines such as putrescine or spermidine. https:\/\/doi.org\/10.1038\/s41598-020-78134-3<\/a><\/p>\n

\n

Histamine belongs to the group of so-called biogenic amines<\/h4>\n<\/blockquote>\n

Humans have three functional genes that encode amines oxidases that contain copper.
\nThe product of the AOC1 gene is the so-called human DiAminoOxidase (hDAO), named for its substrate preference for diamines, particularly histamine. <\/p>\n

The problem arises in some patients when there is an imbalance between histamine intake through food and a deficit in correct degradation<\/strong> through the detoxification systems at the intestinal and hepatic level.
\nThis causes an exaggerated increase in levels in our body with the consequent adverse effects. <\/p>\n

The presence of excess histamine is usually due to a deficiency or inactivity of the DiAminoOxidase enzyme and therefore there is an alteration in the metabolism of food histamine.<\/p>\n

In people with low DiAminoOxidase activity, there is a risk of suffering an alteration known as food histaminosis<\/strong> or histamine intolerance.<\/p>\n<\/p>\n

\"\"<\/p>\n<\/p>\n

\n\tWhat is DAO deficiency?<\/strong><\/h1>\n

DAO deficiency is when there is a deficit in the amount<\/strong> or decrease in the activity of the<\/strong> metabolizing<\/strong> enzyme.
\nThe situation may also arise due to an imbalance between the histamine ingested with food and the ability to metabolize it by this enzyme.
\nThe true mechanism of histamine intolerance is under investigation, but it is known to be related to excessive histamine accumulation<\/strong>. <\/p>\n

\n

Histamine intolerance originates when there is an imbalance between the accumulation of histamine in the blood and the body’s ability to degrade it.<\/h4>\n<\/blockquote>\n

In a healthy individual, histamine is regularly broken down with the help of two enzymes: DAO and HNMT.
\nThe mechanism of histamine intolerance is thought to be due to the presence of a genetic or acquired dysfunction in one of these two enzymes.
\nThe DAO enzyme, which is most often linked to this deficiency disorder, is produced in the gut, so if bowel function is compromised, there may not be enough enzyme to break down histamine normally. <\/p>\n

As there is an increased amount, histamine is not metabolized or degraded correctly, so it manages to penetrate through the intestinal cells, passing into the bloodstream and triggering the different symptoms.<\/p>\n<\/p>\n

\n\tWhat foods contain histamine?<\/strong><\/h1>\n

Unlike a food allergy, where there is an increased presence of immunoglobulin E, in DAO deficiency, the appearance of symptoms is not linked to the consumption of a specific food<\/strong>, but can be associated with a wide range of foods containing different levels of histamine.<\/p>\n

\n

Histamine, unlike allergy, is associated with accumulation due to the consumption of a wide range of foods containing histamine levels<\/h4>\n<\/blockquote>\n

In some people, symptoms may even appear after the consumption of products with low levels of histamine, which raises doubts and further studies should be carried out to confirm any other affectation.<\/p>\n

The histamine content of foods varies depending on their storage time, ripeness, cooking and\/or processing<\/strong>.
\nCertain foods that do not contain high levels of histamine are rich in compounds known as “histamine releasers” that can trigger similar symptoms. <\/p>\n

Histamine is present to a greater or lesser extent in all foods, whether of animal or vegetable origin.
\nFoods that undergo a long maturation or that are stored for an extended period of time, have a particularly high content of histamine and other biogenic amines that are also degraded by the DAO enzyme. <\/p>\n

Foods with higher histamine content include, for example:<\/p>\n