{"id":5178,"date":"2021-07-06T00:00:00","date_gmt":"2021-07-06T00:00:00","guid":{"rendered":"https:\/\/salengei.com\/therapeutic-effects-of-resveratrol\/"},"modified":"2021-07-06T00:00:00","modified_gmt":"2021-07-06T00:00:00","slug":"therapeutic-effects-of-resveratrol","status":"publish","type":"post","link":"https:\/\/salengei.com\/en\/blog\/therapeutic-effects-of-resveratrol\/","title":{"rendered":"Therapeutic Effects of Resveratrol"},"content":{"rendered":"<p>When it was detected that regular consumption of red wine was associated with a lower incidence of cardiovascular disease in France (despite the patterns of a diet rich in saturated fats), research began to be carried out on what this could be the reason for.<br \/>\nIt was discovered that these properties could be attributed to a polyphenol called Resveratrol.<br \/>\nIt is also found in many plants, including grapes, peanuts, berries, and <em>Polygonum cuspidatum<\/em>, a herbaceous plant that grows very easily in temperate zones.    <\/p>\n<\/p>\n<h1>  What is Resveratrol?<\/h1>\n<p>Resveratrol is a stilbene which is known for its ability to provide plants with resistance to microbial and fungal infections.  <\/p>\n<p>As a result of the French paradox and the fact that it was shown to mimic the effects of calorie restriction, the <strong>anti-aging effect<\/strong> was attributed to it.<\/p>\n<blockquote>\n<h4 align=\"center\">  Cardioprotective, antioxidant, immunomodulatory, anti-inflammatory and chemopreventive.<\/h4>\n<\/blockquote>\n<div>  Preliminary in vitro results and animal findings showed that:<\/div>\n<ul class=\"rteindent1\">\n<li>  \u00b7 Favorably modulated lipoprotein metabolism<\/li>\n<li>  \u00b7 It decreased the biosynthesis of thromboxane B2 and eicosanoids related to the inhibition of platelet aggregation.<\/li>\n<\/ul>\n<h4>\n\t<span style=\"color: rgb(77, 77, 77); font-family: Montserrat; font-size: 16px; font-weight: 300;\">Due to its <\/span><strong style=\"color: rgb(77, 77, 77); font-size: 16px;\">antimutagenic, antiproliferative, pro-apoptotic effects<\/strong><span style=\"color: rgb(77, 77, 77); font-family: Montserrat; font-size: 16px; font-weight: 300;\">, resveratrol has gained substantial attention for the treatment of cancer or autoimmunity, and for the initiation and progression of many diseases.<\/span><\/h4>\n<\/p>\n<h1>  Health Effects of Resveratrol<\/h1>\n<p>One of the protective mechanisms of cancer is because it enables autophagy, a mechanism that is responsible for eliminating waste or excess damaged proteins and organelles.  <\/p>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1568163712000529\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1568163712000529<\/a><\/p>\n<p>  Autophagosomes act in a similar way to modern vacuum cleaners\/home robots.<br \/>\nThat is, they move around the cell interior and &#8220;gobble up&#8221;, as if they were vacuuming up the accumulated dust. <\/p>\n<p><strong>Autophagy deficiency favors the pathogenesis<\/strong> of many diseases that occur especially at older ages, such as neurodegenerative diseases and cancer.  <\/p>\n<blockquote>\n<h4 align=\"center\">  Resveratrol activates autophagy<\/h4>\n<\/blockquote>\n<p>Resveratrol has been shown to activate SIRT1, which precisely activates autophagy.<br \/>\nThis <strong>SIRT1 activation<\/strong> pathway (which mimics the effects of calorie restriction) improves many aspects such as: <\/p>\n<ul>\n<li style=\"margin-left: 39pt;\">  \u00b7 Resistance to stress<\/li>\n<li style=\"margin-left: 39pt;\">  \u00b7 Cell survival<\/li>\n<li style=\"margin-left: 39pt;\">  \u00b7 Cellular senescence<\/li>\n<li style=\"margin-left: 39pt;\">  \u00b7 Immune function to inflammation<\/li>\n<li style=\"margin-left: 39pt;\">  \u00b7 Endothelial functions<\/li>\n<li style=\"margin-left: 39pt;\">  \u00b7 Circadian rhythms<\/li>\n<li style=\"margin-left: 39pt;\">\n\t\t <\/li>\n<li>  Resveratrol is a pleiotropic molecule that is sometimes controversial and has very complicated functions that deserve special attention, such as its hormonal function.<\/li>\n<\/ul>\n<p>But first I will start by mentioning different aspects of its therapeutic potential.<\/p>\n<p> <img decoding=\"async\" alt=\"\" src=\"http:\/\/salengei.com\/wp-content\/uploads\/grape-4594464_1920.jpg\" style=\"width: 800px; height: 534px;\"><\/p>\n<h2>  Obesity<\/h2>\n<p>One study that included 28 randomized controlled trials that reviewed the effects of resveratrol supplementation on body weight (BW), body mass index (BMI), waist circumference (WC), and fat mass (FM).<br \/>\nThe results of the subgroup analysis revealed a significant reduction in body weight and BMI in trials using resveratrol at doses of &lt;500 mg d-1, in those cases where the interventions lasted (\u22653 months) and performed in people with obesity. <\/p>\n<p><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1111\/obr.12775\">https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1111\/obr.12775<\/a><\/p>\n<\/p>\n<h1>  Cardiovascular protection<\/h1>\n<p>Atherosclerosis is a disease that is characterized by calcification of the arteries and this in turn is caused by the oxidation of LDL cholesterol.<\/p>\n<p>What usually happens is that monocytes, after penetrating the subendothelial space, are phagocytosed and transform into macrophage foam cells.<br \/>\n <strong>Resveratrol acts by inhibiting the expression of monocyte chemoattractant protein 1 (MCP-1).<\/strong><br \/>\nOn the other hand, lipoproteins after penetrating the endothelial lumen are oxidatively modified and in turn phagocytosed by receptors on the foam cells.  <\/p>\n<blockquote>\n<h4 align=\"center\">  Resveratrol acts as an antioxidant preventing LDL oxidation making it a protector against atherosclerosis.<\/h4>\n<\/blockquote>\n<p><strong>Resveratrol also increases the production of nitric oxide (NO) in endothelial cells<\/strong>.<br \/>\nBy upregulating the expression of endothelial NO synthase (eNOS), it inhibits tumor necrosis factor-alpha (TNF\u03b1) and angiotensin II (AngII).<br \/>\nTrans-resveratrol interferes with the release of inflammatory mediators by activating PMN and negatively regulating adhesion-dependent thrombogenic PMN functions.  <\/p>\n<p><img decoding=\"async\" alt=\"\" src=\"http:\/\/salengei.com\/wp-content\/uploads\/polygonum_cuspidatum.jpg\" style=\"width: 800px; height: 533px;\"><\/p>\n<p>Resveratrol acts as:<\/p>\n<ul class=\"rteindent1\">\n<li>  \u00b7 Modulator of troponin C-troponin I interactions<\/li>\n<li>  \u00b7 Reduces prolonged activation of cardiac fibroblasts by preventing cardiac fibrosis that would reduce the contractile function of the myocardium<\/li>\n<li>  \u00b7 It reduces the synthesis of endothelin-1, a very potent vasoconstrictor.<br \/>\nOverproduction of ET-1 is implicated in the development of vascular disease and atherosclerosis.   <\/li>\n<\/ul>\n<p><a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2012.00141\/full\">https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2012.00141\/full<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6539341\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6539341\/<\/a><\/p>\n<\/p>\n<h2>  Blood pressure<\/h2>\n<p>A systematic review and meta-analysis of randomized controlled clinical trials evaluated the impact of resveratrol on BP.<br \/>\nThe results of this review showed that the administration of <strong>resveratrol did not significantly affect either systolic BP, diastolic BP or mean BP<\/strong>.<br \/>\nHowever, significant WMD (weighted mean differences) were detected in subsets of studies categorized according to the high daily dose of resveratrol (\u2265300 mg\/day) in patients with diabetes.  <\/p>\n<p>Another meta-analysis of six studies with a total of 247 subjects.<br \/>\nIt concluded that <strong>consumption of resveratrol at a higher dose<\/strong> (\u2265 150 mg\/d) <strong>significantly reduces SBP<\/strong> of -11.90 mmHg (95% CI -20.99, -2.81 mmHg, P = 0.01), whereas the lower dose of resveratrol did not show a significant reducing effect on SBP.   <\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6539341\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6539341\/<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29359958\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/29359958\/<\/a><\/p>\n<\/p>\n<h2>  Anti-inflammatory activity<\/h2>\n<p>Resveratrol exerts <strong>anti-inflammatory activity<\/strong> through many pathways:<\/p>\n<ul class=\"rteindent1\">\n<li>  \u00b7 It inhibits the activity of cyclooxygenase 1 and 2 (COX1 and 2), nuclear factor kappa B (NF-kB).<\/li>\n<li>  \u00b7 At the intestinal level, resveratrol reduces inflammatory injury, activity of TNF-a, IL-6, and other mechanisms that protect the gut from inflammatory injury.<\/li>\n<li>  \u00b7 Studies have also shown that the estrogenic activity of resveratrol can mitigate inflammatory and oxidative lesions after ischemia\/reperfusion brain lesions.<br \/>\nResveratrol significantly reduced the area of infarction after reperfusion. <\/li>\n<\/ul>\n<h1>  Resveratrol de Salengei<\/h1>\n<p>At Salengei we have different formulas at different doses:<\/p>\n<ul class=\"rteindent1\">\n<li>  \u00b7 <a href=\"http:\/\/salengei.com\/active-resveratrol\">Active Resveratrol 500 mg\/ capsule<\/a><\/li>\n<li>  \u00b7 <a href=\"http:\/\/salengei.com\/active-detox\"> Active Detox<\/a><\/li>\n<li>  \u00b7 <a href=\"http:\/\/salengei.com\/active-silueta\"> Active Silhouette<\/a><\/li>\n<li>  \u00b7 <a href=\"http:\/\/salengei.com\/phytomatrix\">PhytoMatrix<\/a><\/li>\n<\/ul>\n<div>\n<blockquote>\n<h4 class=\"rtecenter\">  Natural dietary levels (estimated in Europe to be in the range of 0.01 to 0.45 mg per day)<\/h4>\n<\/blockquote>\n<\/div>\n<p><a href=\"http:\/\/salengei.com\/active-resveratrol\"><img decoding=\"async\" alt=\"\" src=\"http:\/\/salengei.com\/wp-content\/uploads\/as-_200930-_banner_active_resveratrol.jpg\" style=\"width: 800px; height: 373px;\"><\/a><\/p>\n<\/p>\n<h1>  Resveratrol as a Phytoestrogen: Endocrine Action<\/h1>\n<p>Resveratrol is a plant-based polyphenolic stilbene, structurally similar to natural and synthetic estrogens and has been classified as a phytoestrogen because:  <\/p>\n<ol>\n<li>  It interacts with ER Estrogen Receptors and modulates their genomic and non-genomic activities.<br \/>\nWith mixed agonist and antagonist function due to the tissue-specific expression of Er\u03b1 and ER\u03b2 (Henry and Witt <a href=\"https:\/\/translate.googleusercontent.com\/translate_f#23\">2002<\/a>). <\/li>\n<li>  It inhibits several enzymes in steroidogenesis and competes in estrogen metabolism.  <\/li>\n<li>  Consumption of 0.5 to 1 g per day provides sufficient plasma levels to initiate the pleiotropic hormonal activities of resveratrol, which opens up an opportunity for clinical benefit, but also risk of endocrine disruption if exposure is chronic or for a long time.<\/li>\n<\/ol>\n<p>But since this hormonal regulation effect is long and complex, I leave you this preamble and to develop it in the next post.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In this post, Dr.<br \/>\nGloria Sabater tells us about the benefits of consuming Resveratrol   <\/p>\n","protected":false},"author":2,"featured_media":2732,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[334],"tags":[],"class_list":["post-5178","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-anti-aging"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Therapeutic Effects of Resveratrol - Salengei<\/title>\n<meta name=\"description\" content=\"In this post, Dr. Gloria Sabater tells us about the benefits of consuming Resveratrol\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/salengei.com\/en\/blog\/therapeutic-effects-of-resveratrol\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Therapeutic Effects of Resveratrol - Salengei\" \/>\n<meta property=\"og:description\" content=\"In this post, Dr. Gloria Sabater tells us about the benefits of consuming Resveratrol\" \/>\n<meta property=\"og:url\" content=\"https:\/\/salengei.com\/en\/blog\/therapeutic-effects-of-resveratrol\/\" \/>\n<meta property=\"og:site_name\" content=\"Salengei\" \/>\n<meta property=\"article:published_time\" content=\"2021-07-06T00:00:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/salengei.com\/wp-content\/uploads\/adobestock_374153335baja.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"1896\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Dra. 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