{"id":5177,"date":"2021-06-21T00:00:00","date_gmt":"2021-06-21T00:00:00","guid":{"rendered":"https:\/\/salengei.com\/uses-of-berberine-in-the-eradication-of-helicobacter-pylori\/"},"modified":"2021-06-21T00:00:00","modified_gmt":"2021-06-21T00:00:00","slug":"uses-of-berberine-in-the-eradication-of-helicobacter-pylori","status":"publish","type":"post","link":"https:\/\/salengei.com\/en\/blog\/uses-of-berberine-in-the-eradication-of-helicobacter-pylori\/","title":{"rendered":"Uses of Berberine in the eradication of Helicobacter pylori"},"content":{"rendered":"

Did you know that Berberine is effective in eliminating Helicobacter pylori<\/em><\/strong>?
\nIn this post we talk about a pathology that, according to some studies, has an incidence of more than 50% in our society and in which until recently there were almost no therapeutic options; We are talking about chronic gastritis<\/strong>. <\/p>\n

In today’s article we will expose the most relevant characteristics of this condition, the medical case to treat it and an interesting therapy that is an innovation in the eradication of the most identified infectious cause, Helicobacter pylori<\/strong>.<\/p>\n<\/p>\n

The causes we now know <\/h1>\n

Let’s make a little history and go back to the year 1983.
\nAt that time it was thought that chronic gastritis was caused by some types of food (especially spicy ones<\/strong>) and this cause influenced according to the personality of the person.
\nIt was then said that a combination of stress, together with an external aggressor such as certain types of food, produced chronic gastritis and most gastric ulcers. <\/p>\n

Today we know that chronic gastritis has <\/span>different causes<\/strong> and as for those of infectious etiology, there are some microorganisms that can cause chronic inflammatory lesions.
\nThe germ most frequently identified in chronic gastritis of the antrum and those associated with duodenal ulcer is Helicobacter pylori. <\/span><\/p>\n

\n

What they did not know is that their gastritis was possibly due to a bacterium, Helicobacter pylori.<\/h4>\n<\/blockquote>\n

We must not leave aside epigenetics<\/strong>, which tells us about genetic predisposition and the regulation of the expression of certain genes in certain patients to develop this type of disease.<\/p>\n<\/p>\n

Previously, the unknown Helicobacter pylori<\/em><\/h1>\n

\"\"<\/p>\n

The discovery that most chronic gastritis was caused by an infectious agent gave a lot to talk about.
\nThis discovery was made by two Australian doctors who won the Nobel Prize in Medicine and Physiology in 2005<\/strong>, Robin Warren and Barry Marshall. <\/p>\n

\n

The discovery of Helicobacter pylori was a highly controversial topic<\/h4>\n<\/blockquote>\n

In 1979, for the first time, Warren observed the bacterium in inflamed gastric epithelium and later in gastritis associated with peptic ulcer<\/strong>.
\nUntil that moment it was said that it was impossible for a microorganism to grow in an environment as acidic as the stomach. <\/p>\n

In 1981, Marshall began a collaboration by obtaining cultures, conducting prospective studies and administering therapeutic regimens with antibiotics and bismuth salts.
\nThe bacterium was first called Campylobacter-like, because of its resemblance to this species. <\/p>\n

In 1984, Marshall self-inoculated himself<\/strong> with the agent by ingesting a culture, which caused gastritis.
\nIt was treated and cured with bismuth and metronidazole salts<\/strong>.
\nBoth doctors then presented their findings to the Australian Gastroenterological Association, which rejected the abstract with the preliminary data. <\/p>\n

In 1983, the famous journal Lancet published two different correspondences from the authors, who sent the same material separately.
\nLater, and in collaboration with microbiologists, they classified the new bacterium within the genus Helicobacter<\/em> and as a pylori<\/em> species. <\/p>\n

Currently, gastritis and peptic ulcer are considered infectious diseases<\/strong>.
\nIn addition, the causal relationship<\/strong> between Helicobacter pylori<\/em>, adenocarcinoma and gastric lymphoma has been proven, and its relationship with some extradigestive diseases has been suggested. <\/p>\n

http:\/\/scielo.isciii.es\/scielo.php?script=sci_arttext&pid=S113001082006001000007&lng=es&nrm=iso<\/a><\/p>\n<\/p>\n

How is it treated?<\/h1>\n

\"\"\"\"<\/p>\n

The classic treatment that is usually used includes the triple antibiotic plan. <\/strong>Three antibiotic agents are combined to prevent resistance by the microorganism.
\nThis plan is carried out with clarithromycin, amoxicillin and metronidazole, or salts of bismuth, metronidazole and tetracycline always associated with a proton pump inhibitor.
\nThe duration of the treatment can vary between 7-14 days. <\/p>\n

http:\/\/boletin.ciberisciii.es\/ciberehd\/ciberdetallessubnotica.php?notiID=122&boletinID=22&ciberID=3<\/a><\/p>\n

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In many cases, there is resistance to Helicobacter pylori in antibiotics<\/h4>\n<\/blockquote>\n

On the other hand, despite using the aforementioned combinations, resistance<\/strong> of Helicobacter pylori<\/em> to nitroimidazoles, macrolides, quinolones and rifampicins, among others, has been detected.
\nResistance affects each of the compounds in each group.
\nIn the case of other antibiotics commonly used in eradication therapies, such as amoxicillin and tetracyclines, resistance rates are very low, so the real problem in clinical practice lies mainly in resistance to nitroimidazoles and macrolides. <\/p>\n

https:\/\/scielo.isciii.es\/scielo.php?script=sci_arttext&pid=S1130-01082007000200001<\/a><\/p>\n<\/p>\n

What is Berberine?<\/h1>\n<\/p>\n

Berberine<\/a> is a type of isoquinoline alkaloid isolated from various plants and is widely used in traditional Chinese medicine<\/strong>.
\nAs an antibiotic, Berberine has been used to treat conditions such as diarrhea for many, many years. <\/p>\n

Recently, numerous studies have shown that Berberine has the ability to inhibit Helicobacter pylori<\/em> in vivo and in vitro<\/strong>. https:\/\/doi.org\/10.1002\/jcb.26681<\/a><\/p>\n

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The efficacy of Berberine combined with standard triple therapy to eradicate Helicobacter pylori<\/em> is demonstrated<\/h4>\n<\/blockquote>\n

Berberine can also effectively suppress multidrug-resistant strains of H. pylori<\/em>.
\nIn addition, thanks to the intervention of Berberine, an in vitro model, the minimum inhibitory concentration of amoxicillin and tetracycline for the bacterium was reduced. https:\/\/doi.org\/<\/a><\/u> 10.3748\/wjg.v21.i14.4225<\/a> <\/p>\n

In addition, Berberine can also suppress the expression of pro-inflammatory genes<\/strong> and regulate the expression of anti-inflammatory genes in mice infected with Helicobacter pylori<\/em>. The antimicrobial property of Berberine<\/a> has proven to be of great scientific interest thanks to the decreased efficacy of standard triple therapy.<\/strong> In China, an increasing number of randomized controlled clinical trials confirmed the efficacy of Berberine combined with standard triple therapy for the eradication of Helicobacter pylori<\/em>.<\/p>\n

\"\"<\/a><\/p>\n<\/p>\n

Adding strategies<\/h1>\n

As always, the sum of the parts is the best treatment<\/strong>.
\nA group of researchers in China set out to review an extensive database of randomized studies and concluded that the addition of Berberine to the therapy consisting of two antibiotics plus a proton pump inhibitor significantly improved the eradication rate of<\/strong> Helicobacter pylori. <\/p>\n

It was also seen:<\/p>\n