During the growth stage, our body is quicker at building and repairing than the rate of damage. In the adult stage there is a balance, that is, our state of health controls the balance between the elimination of damaged cells via apoptosis and the proliferation and recovery by new cells. Once the reproductive phase has ended and the mature stage has started, the destruction processes occur more rapidly than the construction and repair processes, which is why the ageing process is accentuated.
Biological importance of telomeres
Telomeres are specialised structures located at each end of chromosomes, and their main functions are to protect the cell from DNA damage caused by breakages that occur in this area. They are formed by repeated sequences of TTAGGG which, together with specialized proteins, form a structure similar to a hood, protecting the cell from DNA damage caused by breaks that occur gradually by erosion with each cell division cycle. In fact, telomere length provides information about the number of times a cell has divided ("mitotic clock"), as it shows the balance between losses and additions of TTAGGG repeats. Telomere loss is typically attributed to the problem of replication of the end part, and is clearly accelerated by other factors such as oxidative stress and inflammation.
In addition, telomerase is the enzyme responsible for the maintenance of telomere length through the addition of guanine-rich repetitive sequences. When telomerase works well, there is better maintenance of telomeres This highlights its potential role in delaying old age and living healthily.
Each time a cell divides, it duplicates its DNA, including the base sequence constituting the telomere. But this process of replication is not able to copy the entire telomere sequence, so it becomes progressively shorter and telomeric DNA is gradually lost. When the telomere is very short, the cell can not divide further and it dies, and that is why we age.
TA-65® and TA SCIENCES
Geron Corporation is a pioneer in the development of therapies capable of stimulating the activity of telomerase in normal cells without affecting cancer cells with an uncontrolled proliferation, and in the search for therapies aimed at slowing the deterioration caused by the natural process of celular ageing, by preserving telomere length.
In the year 2000, Geron Corporation discovered TA-65®, a molecule from the astragalus plant, capable of activating telomerase and repair short telomeres.
In 2002, Noel Patton founded T.A. SCIENCES and got the licence and worldwide rights for telomerase activation technology and for the product discovered by Geron Corporation, so that it could be used as a dietary supplement or in cosmetics. After five years of development and safety studies, and with medical supervision from the Patton protocol designed by his team of expert scientists, TA SCIENCES made TA-65® available to the public.
TA-65®, the result of an investigation by Telomerase Activation Sciences, is a dietary supplement containing astragalus extract, used in studies to check the effects on telomere repair and on some aspects of health improvement.
There is a certain dissimilarity between chronological age --which gives us information about the ageing of our cells and indicates our real age as opposed to our life expectancy-- and our biological age --which is marked by our real age from the point of view of the ageing of our cells, organs, biological systems, skin, etc, and to which we sometimes refer when we say "you look younger", or "he or she looks older".
A trustworthy product
TA-65® has been used by thousands of people since 2005 and no adverse side effects have been reported. It has the Generally Recognized as Safe (GRAS) certification. Each batch of TA-65® is thoroughly tested and manufactured in the USA under the conditions established by a competent body
• Improvement of the immune system.
• Skin's appearance.
• Prevention of age-related pathologies.
• From 25 to 50 years of age: 1 capsule daily.
• From 50 to 70 years of age: 2 capsules daily.
• Over 70 years of age: 4 capsules daily.
Best taken on an empty stomach.
TA-65 30 capsules (100 units).