Homocrystol®+ TMG

Active
National Code: 212915.3

60 capsules

Dietary supplement formulated with vitamins B2, B6, folic acid, B12, betaine and choline that contribute to the normal metabolism of homocysteine.

Product Features

Homocrystol®+ TMG
Vegan
Homocrystol®+ TMG
Gluten free
Homocrystol®+ TMG
Lactose free

Product benefits

Homocysteine control
Heart
Cardiovascular Health

Product Features

Homocrystol®+ TMG
Vegan
Homocrystol®+ TMG
Gluten free
Homocrystol®+ TMG
Lactose free

Main assets ofHomocrystol®+ TMG

Vitamin B2 or Riboflavin

(Riboflavin)
Contributes to normal energy metabolism.

Vitamin B6 or Pyridoxine

(Pyridoxine HCL)
Contributes to the normal metabolism of homocysteine.

Quatrefolic® (Vitamin B9 or Folate or Folic Acid)

(5-methyltetrahydrofolate)
Contributes to the normal metabolism of homocysteine.

Vitamin B12 or Methylcobalamin

(Methylcobalamin)
Contributes to the normal metabolism of homocysteine.

Betaine

Contributes to the normal metabolism of homocysteine.

Hill

(Choline Bitartrate)
Contributes to the normal metabolism of homocysteine.
Homocrystol®+ TMG
Vitamin B2 or Riboflavin

Vitamin B2, also called riboflavin, is one of the most widespread water-soluble vitamins. The most important and common dietary sources are milk and dairy products, lean meat, eggs, and leafy greens.
Yeast and liver have the highest concentrations, but they don’t have much relevance in today’s nutrition. Among its functions, vitamin B2 contributes:

  • to normal energy metabolism.
  • to the protection of cells against oxidative damage.
  • to the normal functioning of the nervous system.
  • to the maintenance of mucous membranes under normal conditions.
  • to the maintenance of red blood cells under normal conditions.
  • to the maintenance of the skin in normal conditions.
  • to the maintenance of vision under normal conditions.
  • to normal iron metabolism.
  • Helps to reduce tiredness and fatigue.
Vitamin B6 or Pyridoxine

Vitamin B6 is a water-soluble vitamin.
There are three natural forms of vitamin B6: pyridoxine, pyridoxamine, and pyridoxal, and all are normally present in food, however, pyridoxine is the most well-known form. Sources of vitamin B6 (pyridoxine) are chicken, beef, especially liver, and pork.
Good sources include fish (salmon, tuna, sardines, grouper, and herring), nuts (walnuts, peanuts), bread, corn, and whole grains.
Vegetables and fruit are generally poor sources of vitamin B6. Among its functions, vitamin B6 contributes:

  • to the normal synthesis of cysteine.
  • to normal homocysteine metabolism.
  • to normal energy metabolism.
  • to the normal functioning of the nervous system.
  • to normal protein and glycogen metabolism.
  • to normal psychological function.
  • to the normal formation of red blood cells.
  • to the normal functioning of the immune system.
  • Helps to reduce tiredness and fatigue.
  • to regulate hormonal activity.
Quatrefolic® (Vitamin B9 or Folate or Folic Acid)

Vitamin B9, also called folate, is one of the water-soluble B vitamins.
Its name comes from the word “folia” which means leaf in Latin, due to its natural presence in green leafy vegetables.
Also in beans, wheat germ and yeast.
Other sources include egg yolk, milk and dairy, beetroot, orange juice, and wholemeal bread.
Vitamin B9 is given in different forms: the natural one which is folate and folic acid, which is a synthetic folate compound used in vitamin supplements and fortified foods because it is more stable. Folic acid contributes:

  • to normal psychological function.
  • Helps to reduce tiredness and fatigue.
  • to the growth of maternal tissues during pregnancy.
  • to normal amino acid synthesis.
  • to the normal formation of blood cells.
  • to normal homocysteine metabolism.
  • to the normal functioning of the immune system.
  • to the process of cell division.

Tiredness and fatigue associated with stress can be a causative factor in hair loss.
In food supplements, folate is usually found in the form of folic acid, but different salts such as 5-MTHF (methylfolate) can also be used.
Quatrefolic® glucosamine salt (6S)-5-methyltetrahydrofolate (5-MTHF).
The source of folic that is selected is very important.
Dietary supplements containing 5-MTHF may be better than folic acid for some people who have a gene mutation called MTHFR C677T because their bodies can use this form more easily.
This is because the body cannot transform the synthetic folic or folic present in fruits and vegetables into its methylated active form.
That is why our formulas contain Quatrefolic® (5-MTHF).
Quatrefolic® is a fourth-generation folate.
It is a registered trademark of Vitamin B9, (also known as Folate).
It is the glucosamine salt of (6S)-5-methyltetrahydrofolate (5-MTHF) and is structurally identical to the reduced, active form of folate found in our bodies. It is an innovative dietary ingredient that provides greater stability, improved bioavailability, higher water solubility, and flexibility for multi-ingredient formulations compared to a third-generation 5-MTHF calcium salt. In recent years, more and more evidence has been found of the advantages of reduced folate over folic acid.
The use of reduced folate (particularly reduced and methylated as Quatrefolic®) is the solution since a large part of the world’s population cannot assimilate and metabolize folic acid from foods or food supplements.
Quatrefolic® is manufactured under controlled conditions according to cGMP and since glucosamine does not come from animals or shellfish, Quatrefolic ® is a great choice for vegetarians.
In addition, Quatrefolic® is considered safe and is recognized as GRAS.

1. Patanwala I et al. Folic acid handling by the human gut: implications for food fortification and supplementation. Am J Clin Nutr. 2014

2. Scaglione F, Panzavolta G. Folate, folic acid and 5-methyltetrahydrofolate are not the same thing. Xenobiotica. 2014

3. Ulrich CM, Potter JD. Folate supplementation: too much of a good thing? Cancer Epidemiol Biomarkers Prev. 2006

4. Pietrzik K et al. Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics. Clin Pharmacokinet. 2010

5. Lawrence, Kripalani et al. « Profiling National Mandatory Folic Acid Fortification Policy Around the World. » New York: Springer; 2012

6. Ulric et al. « Folate Supplementation: Too Much of a Good Thing? » Cancer Epidemiol Biomarkers Prev 2006;15:189-193

7. Strum et al. « Enzymatic reduction and methylation of folate following pH-dependant, carrier-mediated transport in rat jejunum. » Biochim Biophys Acta 1979; 554, 249-257

8. Kelly et al. « Unmetabolized folic acid in serum: acute studies in subjects consuming fortified food and supplements. » Am J Clin Nutr 1997:65:1790-5

9. Jamil K. Clinical Implications of MTHFR Gene Polymorphism in Various Diseases. Biol Med. 2014

10. Wilcken B et al. Geographical and ethnic variation of the 677C>T allele of 5,10 methylenetetrahydrofolate reductase (MTHFR): findings from over 7000 newborns from 16 areas worldwide. J Med Genet. 2003

11. Seremak-Mrozikiewicz A et al. The significance of 1793G>A polymorphism in MTHFR gene in women with first trimester recurrent miscarriages. Neuro Endocrinol Lett. 2010

12. Tsang BL et al. Assessing the association between the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism and blood folate concentrations: A systematic review and meta-analysis of trials and observational studies. Am. J. Clin. Nutr. 2015

13. Sweeney MR et al. Persistent circulating unmetabolized folic acid in a setting of liberal voluntary folic acid fortification. Implications for further mandatory fortification? BMC Public Health. 2009

14. Smith AD. Folic acid fortification: the good, the bad, and the puzzle of vitamin B-12. Am J Clin Nutr. 2007

15. Smith D. A. et al. Is folic acid good for everyone? Am J Clin Nutr. 2008

16. Colman, Green, Metz et al. « Prevention of folate deficiency by food fortification. Il. Absorption of folic acid from staple foods. » Am J Clin Nutr I 975; 28:459-64

17. Shils et al. « Modern Nutrition in Health and Disease, 9th ed ». Williams & Wilkins, Balt., 1999

18. http://www.efsa.europa.eu/it/home/publication/efsafolicacid.pdf

19. Morris MS et al. « Circulating unmetabolized folic acid and 5-methyltetrahydrofolate in relation to anemia, macrocytosis, and cognitive test performance in American seniors ». Am J Clin Nutr. 2010

Vitamin B12 or Methylcobalamin

Vitamin B12 is the largest and most complex of the vitamins.
Vitamin B12 comprises the only cobalt-containing molecules (called cobalamins) with biological activity in humans. Vitamin B12 is produced exclusively by microbial synthesis in the digestive tract of animals.
Therefore, people who follow a vegetarian or vegan diet have to provide this vitamin through food supplements. It is obtained from products with animal proteins, especially organ meats.
Other good sources include fish, eggs, and dairy products. Among its functions, vitamin B12 contributes:

  • to normal homocysteine metabolism.
  • to normal energy metabolism.
  • to the normal functioning of the nervous system.
  • to normal psychological function.
  • to the normal formation of red blood cells.
  • to the normal functioning of the immune system.
  • Helps to reduce tiredness and fatigue.
  • to the process of cell division.
Betaine

Betaine, also known as trimethylglycine, is a non-essential nutrient that contributes to the production of hydrochloric acid in the body.
Hydrochloric acid is essential for the absorption of vitamin B12, calcium and iron. It is synthesized from choline and can also be obtained through the diet.
Food sources such as beets, liver, eggs, fish, legumes, and whole grains. Betaine is used to treat homocysteinuria, which is the elevation of homocysteine levels in the blood.
Its main function is that it contributes to the normal metabolism of homocysteine.
The beneficial effect is obtained with a daily intake of 1.5 g of betaine. Betaine contributes:

  • to normal homocysteine metabolism.
Hill

Choline is an essential nutrient that belongs to the group of B vitamins. It is not a vitamin as it can be synthesized in small amounts in the liver.
Most of the choline found in the body comes from the food you eat.
Among its sources, it can be obtained from meat, eggs and dairy products.
It is also obtained from cruciferous vegetables such as Brussels sprouts, broccoli and cauliflower and some types of beans, nuts, seeds and whole grains. On the other hand, choline is very important for cell membranes and for producing acetylcholine, a neutrotransmitter.
Therefore, it plays an important role in memory and muscle control. Among its functions, the hill contributes:

  • to normal homocysteine metabolism.
  • to normal lipid metabolism.
  • to maintain normal liver function.

Recent studies suggest that, in addition to the properties of choline for the proper functioning of organs such as the liver or brain, they can also contribute to maintaining the muscular system and reducing cardiovascular risk.

Product Description

Nutritional information

Description

What is homocysteine and why it should be monitored Having elevated homocysteine levels in the blood, a condition known as hyperhomocysteinemia, can be indicative of several health problems.
Some of the common causes of elevated homocysteine levels include:

  1. Vitamin deficiencies: Deficiencies of B vitamins, especially B6, B12, and folate (B9), can lead to increased homocysteine levels.
    These vitamins are essential for the metabolization of homocysteine.
  2. Genetics: Genetic variations, such as mutations in the MTHFR (methylenetetrahydrofolate reductase) gene, can affect the body’s ability to process homocysteine.
  3. Kidney disease: The kidneys play a role in removing homocysteine from the blood, and kidney dysfunction can result in elevated levels.
  4. Lifestyle factors: Excessive alcohol consumption, smoking, and improper diet can contribute to high homocysteine levels.
  5. Medications: Some medications can interfere with homocysteine metabolism.

Elevated homocysteine levels are associated with several health risks, such as:

  • Cardiovascular disease, complications during pregnancy: In pregnant women, high homocysteine levels can increase the risk of complications such as preeclampsia, preterm birth and fetal development problems, and osteoporosis

To manage and reduce elevated homocysteine levels, doctors may recommend:

  • Supplementation of vitamins B6, B12 and folic acid in their methylated form such as Quatrefolic and methylcobalamin, Betaine or TMG, choline : These vitamins help metabolize homocysteine.
  • Dietary improvements: Include folate-rich foods, such as leafy greens, fruits, and legumes.
  • Lifestyle modifications: Reduce alcohol consumption, quit smoking, and maintain a balanced diet.

It is important to consult a doctor to properly assess homocysteine levels and determine the most appropriate treatment plan.

How to take Homocrystol®+ TMG

2 capsules a day.

Presentation

60 capsules

Indications

  • Contributes to the normal metabolism of homocysteine.

Ingredients

Betaine Hydrochloride, Magnesium Bisglycinate, Capsule (Glazing Agent: Hydroxypropyl Methylcellulose), Choline Bitartrate, Corn Maltodextrin, Vitamin B12 (Methylcobalamin), Vitamin B2 (Riboflavin), Vitamin B6 (Pyridoxine Hydrochloride), Thickener (Gum Arabic), Vegesil, Amorphous Silica of Rice (Oryza sativa), Quatrefolic® (Acid (6S)-5methyltetrahydrofolate, Glucosamine Salt) folate.

Contraindications / Allergens

They have not been described.

Warnings

Dietary supplements should not be used as substitutes for a varied and balanced diet or a healthy lifestyle.
Do not exceed the recommended daily dose.
Keep out of reach of young children.
Only recommended for adults.

Homocrystol®+ TMG
Vegan
Homocrystol®+ TMG
Gluten free
Homocrystol®+ TMG
Lactose free
Nutritional Information
IngredientsDaily Dose%NRV
Vitamin B2 (riboflavin)33 mg2.357%
Vitamin B6 (pyridoxine) - (pyridoxine hydrochloride)21 mg 1.500%
Vitamin B9 Quatrefolic® (5-methyltetrahydrofolate)500 μg250%
Vitamin B12 (methylcobalamin)600 μg24.000%
Betaine (trimethylglycine)600 mg
Choline (Bitartrate)100 mg

NRV: Nutrient Reference Value.
*%NRV not defined.

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