Berberine

Active

60 Capsules

Dietary supplement based on dry extract of barberry (Berberis aristata DC.), white mulberry extract (Reducose®), vitamin E and chromium that helps maintain glucose levels under normal conditions.

Product Features

Berberine
Vegan
Berberine
Gluten free
Berberine
Lactose free

Product benefits

Glucemia
Lipids
Cardiovascular Health
Heart

Product Features

Berberine
Vegan
Berberine
Gluten free
Berberine
Lactose free

Main assets ofBerberine

Indian Barberry Extract

(Berberis aristata DC.)
Barberry extract contains a phytochemical component known as Berberine.

Berberine

(Berberis vulgaris L.)
Berberine is a component extracted from the Barberry plant with studies related to metabolic syndrome.

Reducose® (White Mulberry Extract)

(White mulberry extract)
Aqueous extract of white mulberry leaf, with studies showing that it converts sugars into slow carbohydrates.

DNJ

(Deoxynojirimycin)
1-deoxynojirimycin (DNJ) is the standardised active substance extracted from the white mulberry leaf (Morus alba).

Vitamin E

(D-alpha-tocopherol)
Contributes to the protection of cells against oxidative damage.

Chromium

(Chromium Picolinate)
Helps maintain normal blood glucose levels.
Berberine
Indian Barberry Extract

Barberry (“Berberis aristata DC.“) is a species of shrub in the Berberidaceae family.
The golden yellow coloration of the stem and bark is due to the presence of berberine. Barberry extract contains this phytochemical component known as Berberine, which has been shown in numerous studies to have positive effects on the control of parameters related to metabolic syndrome.

Berberine

Berberine is a phytochemical component extracted from the Barberry plant (Berberis aristata DC).
For thousands of years it has been used in traditional Chinese medicine and Ayurvedic medicine to treat digestive problems and inflammatory conditions. Berberine has now become popular as the “Ozempic of nature” as it has been shown in numerous studies to have positive effects on the control of parameters related to metabolic syndrome.

  • Supports liver health.
  • Helps maintain a normal cholesterol level, contributes to a diet to reduce cholesterol.
  • Helps improve blood glucose control.
  • Helps reduce blood triglyceride levels.

In addition, recent studies suggest that berberine may have positive effects on cellular senescence.
It may have an anti-aging effect by acting to prevent diseases related to cellular aging.

Reducose® (White Mulberry Extract)

The white mulberry, scientific name Morus alba, is a tree that belongs to the Moraceae family. Reducose ® is a patented aqueous extract of white mulberry leaf (Morus alba) standardized to 1-deoxynojirimycin (DNJ).
This extract is 5 times more concentrated in DNJ than other mulberry extracts on the market. Reduco has been® shown through scientific studies to convert fast sugars and carbohydrates into slow ones.

  • Reducose® blocks enzymes in the upper digestive system that break down sucrose and carbohydrates into glucose, for about 1 hour
  • This directly lowers blood sugar and insulin variations after meals, which supports a healthy blood sugar level through better “Time Within Range”
  • Reducose® helps maintain a healthy microbiome and, in clinical studies, has not been shown to cause an increase in gastric problems

In addition, white mulberry leaf significantly reduces the breakdown of sugar and starches into glucose causing a better glycemic index.

  • Healthier insulin response.
  • Prevents the sugar from falling.
  • Feeling of fullness for longer.
  • Feed the good bacteria.
  • Moderate weight loss.
  • No unwanted effects.

Schillinger et al., 2023. 13C-sucrose breath test for the non-invasive assessment of environments enteropathy in Zambian adults. Frontiers in Medicine, 9: 904339. (paper demonstrates undigested carbohydrates feed microbiome)

Ding et al., 2023. The impact of mulberry leaf extract at three different levels on reducing the glycemic index of white bread. PLoS ONE, 18 (8): e0288911.

Mafauzy et al., 2022. A Randomized, Placebo-Controlled Crossover Study to Evaluate the Effect of a Natural Powder Blend (Mulberry Leaf Extract [MLE], Vitamin D, Chromium, and Fiber) on Postprandial (PP) Metabolic Response in Type 2 Diabetes (T2D). Diabetes; 71 (Supplement 1): 41-LB.

*Gheldof et al., 2022. Effect of different nutritional supplements on glucose response of complete meals in two crossover studies. Nutrients; 14: 2674.

*Thondre et al, 2021. Mulberry leaf extract improves glycaemic response and insulaemic response to sucrose in healthy subjects: results of a randomised, double-blind, placebo-controlled study. Nutrition & Metabolism; 18:41.

*Wang et al, 2018. Mulberry leaf extract reduces the glycemic indexes of four common dietary carbohydrates. Medicine (2018) 97:34.

Li et al., 2018. Safety evaluation of mulberry leaf extract: acute, subacute toxicity and genotoxicity studies. Regulatory Toxicology and Pharmacology; 95: 220-226.

*Lown et al, 2017. Mulberry extract improves glucose tolerance and decreases insulin concentrations in normoglycaemic adults: results of a randomized double-blind placebo controlled study. PLOS ONE.

*Liu et al, 2016. Prevention effects and possible molecular mechanism of mulberry leaf extract and its formulation on rats with insulin sensitivity. PLOS ONE.

*Lown et al, 2016. Mulberry extract Reducose® total blood glucose in normoglycaemic adults. Diabetes UK Annual Conference

*Marx et al, 2016. 28-day repeat dose toxicological study of an aqueous extract on Morus alba. L. Int. J. Tox.

*Lown et al, 2015. Mulberry extract to modulate Blood glucose Responses in normoglycaemic adults (MULBERRY) study protocol for a randomized controlled study. TRIALS.

REDUCE Study (2021): Reducose® mulberry extract dose-range study: understanding the impact on complex meals – a randomised, placebo controlled clinical trial

PYN-IM-002a, 2014. An open label, single center clinical study to assess the effects of Reducose® (5%) on the glycaemic index of common carbohydrates in an Indian population

The effect of Reducose® on glucose tolerance in normal Wistar rats.

DNJ

1-deoxynojirimycin (DNJ) is the standardised active substance extracted from the white mulberry leaf (Morus alba) and has a structure close to that of glucose.
This similarity makes it possible to prevent complex sugars from breaking down and passing into the bloodstream before being used by cells or stored.
Therefore, DNJ prevents a rapid rise in blood glucose levels.
Reducose® is 5 times more concentrated in DNJ than other mulberry extracts on the market.
Reduco has been® shown through scientific studies to convert fast sugars and carbohydrates into slow ones.

  • Reducose® blocks enzymes in the upper digestive system that break down sucrose and carbohydrates into glucose, for about 1 hour*.
  • This directly lowers blood sugar and insulin variations after meals, supporting a healthy blood sugar level through better “Time Within Range”*
  • Reducose® helps maintain a healthy microbiome and, in clinical studies, was not shown to cause an increase in gastric problems.

In addition, white mulberry leaf significantly reduces the breakdown of sugar and starches into glucose causing a better glycemic index.

  • Healthier insulin response.
  • Prevents the sugar from falling.
  • Feeling of fullness for longer.
  • Feed the good bacteria.
  • Moderate weight loss.
  • No unwanted effects.

Schillinger et al., 2023. 13C-sucrose breath test for the non-invasive assessment of environments enteropathy in Zambian adults. Frontiers in Medicine, 9: 904339. (paper demonstrates undigested carbohydrates feed microbiome)

Ding et al., 2023. The impact of mulberry leaf extract at three different levels on reducing the glycemic index of white bread. PLoS ONE, 18 (8): e0288911.

Mafauzy et al., 2022. A Randomized, Placebo-Controlled Crossover Study to Evaluate the Effect of a Natural Powder Blend (Mulberry Leaf Extract [MLE], Vitamin D, Chromium, and Fiber) on Postprandial (PP) Metabolic Response in Type 2 Diabetes (T2D). Diabetes; 71 (Supplement 1): 41-LB.

*Gheldof et al., 2022. Effect of different nutritional supplements on glucose response of complete meals in two crossover studies. Nutrients; 14: 2674.

*Thondre et al, 2021. Mulberry leaf extract improves glycaemic response and insulaemic response to sucrose in healthy subjects: results of a randomised, double-blind, placebo-controlled study. Nutrition & Metabolism; 18:41.

*Wang et al, 2018. Mulberry leaf extract reduces the glycemic indexes of four common dietary carbohydrates. Medicine (2018) 97:34.

Li et al., 2018. Safety evaluation of mulberry leaf extract: acute, subacute toxicity and genotoxicity studies. Regulatory Toxicology and Pharmacology; 95: 220-226.

*Lown et al, 2017. Mulberry extract improves glucose tolerance and decreases insulin concentrations in normoglycaemic adults: results of a randomized double-blind placebo controlled study. PLOS ONE.

*Liu et al, 2016. Prevention effects and possible molecular mechanism of mulberry leaf extract and its formulation on rats with insulin sensitivity. PLOS ONE.

*Lown et al, 2016. Mulberry extract Reducose® total blood glucose in normoglycaemic adults. Diabetes UK Annual Conference

*Marx et al, 2016. 28-day repeat dose toxicological study of an aqueous extract on Morus alba. L. Int. J. Tox.

*Lown et al, 2015. Mulberry extract to modulate Blood glucose Responses in normoglycaemic adults (MULBERRY) study protocol for a randomized controlled study. TRIALS.

REDUCE Study (2021): Reducose® mulberry extract dose-range study: understanding the impact on complex meals – a randomised, placebo controlled clinical trial

PYN-IM-002a, 2014. An open label, single center clinical study to assess the effects of Reducose® (5%) on the glycaemic index of common carbohydrates in an Indian population

The effect of Reducose® on glucose tolerance in normal Wistar rats.

Vitamin E

Vitamin E is a fat-soluble nutrient found in many foods.
It is a very effective antioxidant capable of protecting the body against oxidative damage.
Specifically, it has been proven that it protects unsaturated fatty acids and other easily oxidizable substances.
It also acts in the body by stabilizing other vitamins, particularly vitamin A, as well as other hormones and enzymes.
The biological activity of vitamin E in food depends on the presence of the different tocopherols.
The most important sources of vitamin E are vegetable oils (olive, soybean, palm, strip, sunflower, etc.), nuts, whole grains and wheat germ.
Other sources are seeds and green leafy vegetables.
Among its functions, vitamin E contributes:

  • to the protection of cells against oxidative damage.
Chromium

Chromium is an essential trace mineral that is found in small amounts in all foods.
The best source of chromium is brewer’s yeast.
Others include meat, fish, seafood, and whole grains. The physiological role of chromium has been studied and it has been proven that it enhances the action of insulin, positively influencing the metabolism of macronutrients and the maintenance of normal blood glucose levels. Chromium contributes:

  • to maintain normal blood glucose levels.
  • to normal macronutrient metabolism.

Product Description

Nutritional information

Description

Why can we have high blood glucose levels and what diet should we follow to regulate them? People who overeat carbohydrates such as bread, pasta, rice, soft drinks or fruit juices, alcohol and industrial pastries, may have high blood glucose levels.
This type of diet, if maintained over time, can lead to metabolic problems such as type II diabetes, hypertension problems and high triglycerides.
That’s why a proper diet is so important.
It is recommended to replace simple carbohydrates with whole carbohydrates, adding vegetables and legumes combined with proteins.

How to take Berberine

2 capsules a day. Take 1 capsule 10 minutes before lunch and 1 capsule 10 minutes before dinner.

Presentation

60 Capsules

Indications

  • Contributes to the maintenance of glucose under normal conditions.
  • Contributes to the protection of cells against oxidative damage.

Ingredients

Indian Barberry Bark Dry Extract (Berberis aristata DC.) 97% Berberine Hydrochloride, Vegetable [agente de recubrimiento (hidroxipropilmetilcelulosa)]Origin Capsule, White Mulberry Leaf Dry Extract (Morus alba L.) (Reducose®) 5% DNJ (Deoxynojirimycin), Vitamin E (D-alpha-Tocopheryl Acid Succinate), Thickener (Gum Arabic), Corn Maltodextrin, Bamboo Stem Dry Extract (Bambusa arundinacea (Retz.) Willd.) 70% silica, stabilizer (sodium caprylate), chromium picolinate.

Contraindications / Allergens

If the patient is taking medications that are metabolized through the CYP2D6 and CYP3A4 enzymes, they should review with their doctor the possible specific interactions and results.

Warnings

Dietary supplements should not be used as substitutes for a varied and balanced diet or a healthy lifestyle.
Do not exceed the expressly recommended daily dose.
Keep out of reach of young children. If you are pregnant, talk to your doctor.

Berberine
Vegan
Berberine
Gluten free
Berberine
Lactose free
Nutritional Information
IngredientsDaily Dose%NRV
Extract of Indian Barberry (Berberis aristata DC.), of which: 500 mg
- Berberine hydrochloride485 mg
White mulberry extract (Reducose®) of which:100 mg
- DNJ (deoxynojirimicin)5 mg
Vitamin E (D-alpha-tocopheryl acid succinate)10 mg83,33%
Chromium (chromium picolinate)20 μg50%

NRV: Nutrient Reference Value.
*%NRV not defined.

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