As we all know, winter is approaching and low temperatures predispose us to a drop in our immune system.
That is why today we will dedicate this article to talk about how to strengthen the defenses for this change of season.

A bit of revision

Little is known, scientifically speaking, about why respiratory diseases increase exponentially during the cold months.

Some studies assign the cause to a reduction in vitamin D levels, possibly due to less exposure to sunlight during those months or a decrease in the consumption of fish meat with high levels of omega-3 fatty acids.

Other studies propose a reduction in the ciliary activity of the microvilli of the respiratory system, which leads to a decrease in the sweeping of pathogens.

Whatever the cause, health centers and hospitals see a disproportionate increase in the demand for care every year, especially in infants and older adults.

Omega-3s and inflammation

We have mentioned in previous articles that the oral administration of EPA and DHA results in the synthesis of resolvins, which are a set of anti-inflammatory proteins that modify the composition of the cell plasma membrane.
The change in the fatty acid composition of the cells involved in the inflammatory response also affects the production of inflammation-mediating peptides such as cytokines.
This is why omega-3 fatty acids are so important in resolving the famous cytokine storm that has been seen with COVID-19. https://doi.org/10.3390/nu2030355

EPA and DHA fatty acids may have anti-inflammatory effects

It has been suggested that EPA and DHA fatty acids would have anti-inflammatory effects and play a primary role in managing oxidative stress by improving cell function through changes in gene expression, just as vitamin D does.

ACTIVE Ω3 IMMUNITY contains 800mg of EPA, which is eicosapentaenoic fatty acid.

The ever-present Vitamin C

Viruses are known to awaken the well-known cytokine storms.
In these cases, our practice and scientific studies affirm that it is paramount to increase serum levels of antioxidant agents that would modulate this increased expression of cytokines that would culminate in disproportionate inflammation.

Vitamin C is considered an antiviral agent as it boosts immunity.
The administration of vitamin C increases the survival rate of patients with COVID-19 by attenuating the excessive activation of the immune response.
Vitamin C increases antiviral cytokines and the formation of free radicals, decreasing viral performance.
It also attenuates excessive inflammatory responses and hyperactivation of immune cells. https://doi.org/10.3390/molecules25225346

Vitamin C helps to maintain the immune system in normal conditions

Respiratory viruses, and especially SARS-CoV-2, increase the production of reactive oxygen species that cause significant lung damage, which then leads to the subsequent development of adult respiratory distress syndrome (ARDS).
Vitamin C would have a key role and would be a necessary factor in the management of oxidative stress by modulating and containing the action of free radicals.
Not only because of the existence of an exaggerated increase in the general metabolic demands of the antioxidant, but also to generate a reserve that facilitates the substrate in future demands.
DOI: 10.1186/S13054-018-2191-X

The addition of 80mg of vitamin C in the chemical form of ascorbyl palmitate, makes the formula of ACTIVE Ω3 IMMUNITY much more complete and assimilable.

Recent discoveries of the benefits of Vitamin D

As we have previously talked about in other publications, until a while ago, the association between health and vitamin D only brought to mind the idea of bone strength.
The past pandemic has highlighted discoveries about the positive effects of Vitamin D on our immune system.

Positive effects of Vitamin D on our immune system

Vitamin D would act as a modulator of the proliferation of T helper cells and reduce the production of pro-inflammatory cytokines. According to one study, 25(OH) vitamin D has the ability to stimulate regulatory T lymphocytes through the induction of antigen-presenting cells that express variations of the VDR and CYP27B1 genes.
Apparently, the significant form of vitamin D for the generation of regulatory T lymphocytes was free 25 (OH)D, that is, the one that is not bound to its corresponding transporter protein.
DOI: 10.3390 / nu7064240

In the context of an infectious disease, vitamin D3 appears to enhance chemotaxis, phagocytosis, and antimicrobial protein production.
In one study, this vitamin increased antimycobacterial activity against Mycobacterium tuberculosis by inducing autophagy in monocytes through cathelicidin, a peptide member of the antimicrobial protein family.
DOI: 10.1016/j.chom.2009.08.004

Vitamin K not only in coagulation

Vitamin K2 belongs to the group of menoquinones, which have a very important function in modulating the immune system.
Remember that the most important source of menoquinones is mainly in foods of animal origin, such as meat, dairy and eggs.
Remember that for this source to be profitable, the animals must be fed on green pastures.
On the other hand, there is a part that has a microbial origin and is therefore commonly found in fermented foods, such as cheese and yogurt.

One study showed that MK-7 (a subspecies of menoquinones) modulated the expression of TNF-α, IL-1α, and IL-1β.
In addition to this finding, vitamin K2 would decrease the proliferation of T cells in healthy individuals. https://doi.org/10.1111/odi.12759

ACTIVE Ω3 IMMUNITY contains 50 μg of Vitamin K2-7 (menaquinone-7)

This same subspecies was shown to have protective activity in arterial calcification, produced regression of arterial stiffness and an improvement in vascular elasticity in the population cohorts studied.
Each pearl of ACTIVE Ω3 IMMUNITY contains 2000IU of vitamin D3 in the form of cholecalciferol and 50 micrograms of vitamin K2-7 (menoquinone).

Vitamin A

Vitamin A is crucial for maintaining vision, promoting growth, development, and protecting the integrity of the body’s epithelium and mucous membranes.
It is also known as the anti-inflammatory vitamin due to its critical role in improving immune function.
It is involved in the development of the immune system and plays regulatory roles in cellular immune responses and humoral immune processes.

Vitamin A is involved in the development of the immune system

The vital roles that vitamin A and retinoic acid play in the homeostatic control of the immune system are well known, given the observation that individuals with vitamin A deficiency are unable to control bacterial, viral, and protozoan diseases.

Under activation conditions, macrophages produce inflammatory cytokines such as tumor necrosis factor (TNF) and nitric oxide (NO).
One study looked at the effect of vitamin A and retinoic acid on activated peritoneal macrophages and observed that they drastically inhibited TNF mRNA levels and reduced the NO production of activated macrophages.
Similarly, using cord blood mononuclear cells, as well as the human monocyte cell line THP-1, vitamin A was observed to increase IL-10 secretion and inhibit inflammatory cytokines such as TNFα and IL-12. https://doi.org/10.1038/sj.bjp.0703345

ACTIVE Ω3 IMMUNITY is provided with 500 micrograms of vitamin A in the form of retinyl palmitate.
This chemical form effectuates the action, absorption and use of vitamin A.

Conclusion

As we always say, prevention is the key.
That is why from our laboratory, with our researchers, developers, technical and administrative team, we continue in continuous improvement to be able to offer you the best products for your health care.

ACTIVE Ω3 IMMUNITY contains vitamins A, C, D, and K and trace elements such as selenium and zinc that contribute to the normal functioning of the immune system.
This formulation also contains EPA (eicosapentaenoic fatty acid) omega-3 fatty acids, the presence of which in these beads helps to control the cellular inflammatory processes observed in most pathologies.

Protect yourself from colds with ACTIVE Ω3 IMMUNITY!