Dear readers, once again we welcome you to our blog and this time with an article that will surely interest you a lot.
We have received several emails from you requesting that we deal with a topic that concerns many people but at the same time there is a little shame to touch it and that is the alterations of the intestinal tract.

That is why today we will address this topic that is very interesting, it is closely linked to our well-being and not only that, but you will also see that it can affect issues as important as our immunity.
Let’s go for it!

A bit of history

To begin, let’s demystify some issues and start with history.
Our Roman ancestors took evacuation very seriously and quite differently than we have today.
Apparently, and according to some historians, the Romans had the habit of going to public baths to turn the peristaltic movement into a social activity and there was no privacy as we know it today.
In fact, long conversations were usually held with the neighbors next door while the evacuation was taking place.
As a curious fact, in some locations, the public bathrooms boasted up to a hundred seats.

Active Intestinal Transit is much more

It is not our goal to return to historical issues of the past, but to break the ice a little when it comes to physiological activities.
Moving the bowel, having a bowel movement, going to the bowel movement, or whatever you want to call it, is something natural and when there is an alteration, it must be solved.

That leads us directly to talk about one of our products, which is ACTIVE INTESTINAL TRANSIT.

Let’s talk about dietary fibers

If we only pay attention to the name, it seems that it is a product that contains a little fiber and little else to help with evacuation, but far from this, Active Intestinal Transit is much more.

I encourage you to continue reading to be amazed at the quantity and quality of effects in this add-on.

Dandelion, root and whole plant

First of all, we can say that it contains dandelion, also known scientifically as Taraxacum oficinale.
This plant, apparently native to Eurasia, has proven cholagogue and choleretic effects that have been known since ancient times.
In addition to this, the proven prebiotic, hypoglycemic, anti-inflammatory and antioxidant activity place it in a privileged place within the botanical universe.

Dandelion root is known for its numerous benefits at the level of intestinal microvilli and for its mild prebiotic and laxative effect.
In addition, and taking into account that different parts of the plant could provide even more beneficial effects, each sachet adds up to 400 mg of whole plant powder.

Dandelion has a prebiotic, hypoglycemic, anti-inflammatory and antioxidant effect

Fibrulose is rich in inulin and is a fermentable fiber. Regarding the regulatory activity of bowel function, according to a randomized, double-blind, placebo-controlled study, inulin was shown to be responsible for the significant increase in bowel movement frequency compared to placebo in one study. This was accompanied by a softening of the stool, which manifested itself in a greater sense of well-being in the subjects studied. (10.1080/09637486.2016.1212819)

The prebiotic action would occur by the fermentation of inulin, which favors the growth of anaerobic bacterial colonies, including Bifidobaterium.
These microorganisms are responsible for the formation of short-chain fatty acids (e.g. acetic, propionic and butyric acid) and represent the main carbon flux of the host microbiome’s diet.
Remember that achieving a good intestinal balance is necessary to maintain the health of the host and prevent numerous diseases. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230973/

Other research on dandelion has revealed numerous properties, including its actions as a modulator on certain components of inflammation.
The studied extracts were able to demonstrate suppressive effects on the production of nitric oxide (NO), the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in macrophages stimulated with lipopolysaccharides (LPS).
Among the fractions studied, n-butanol (BuOH) was identified as the most effective in the trials. Taraxacum officinale also contains antiangiogenic, anti-inflammatory, and antinociceptive activities that are demonstrated through inhibition of NO production and COX-2 expression and its excellent antioxidant capacity. https://www.sciencedirect.com/science/article/abs/pii/S0378874107004850

Psyllium

Active Intestinal Transit contains a type of fiber commonly known as Psyllium and whose scientific name is Plantago ovata.
Each sachet contains 1300 mg of this component that is synergistically complemented with Taraxacum officinale. In addition, it is a soluble fiber but of a non-fermentable type.
In addition to this, one of the most important characteristics is that, once hydrated, it forms a neutral arabinoxylan-type polysaccharide that has numerous branches, which absorb water from the surrounding environment.
This gel function is critical, not only because it lubricates the stool but also contributes to rescuing the surplus water in the intestinal lumen, so common in diarrhea. https://www.sciencedirect.com/science/article/abs/pii/S0008621504002381

Psyllium is a soluble non-fermentable fiber

Another function of Psyllium to highlight and that helps in aspects related to cardiovascular health, is to contribute to regularizing the normal values of Lipoprotein A. This marker, which is very important in the transport of cholesterol in the blood, is quite complex to reduce even with specific drugs.
In patients studied by a collaborator in our laboratory, the Dr.
Laura Coloma , a significant reduction in Lipoprotein A has been seen through the administration of Active Intestinal Transit.

Fig fiber

So far we have seen the components of Active Intestinal Transit that provide fiber, which is very important.
We would not like to forget to mention the great contribution that means adding 600 mg of fig fiber, which considerably increases the synergy with the two other fibers that we mentioned in the previous paragraphs.

Supplements with fiber should be taken with plenty of water to avoid constipation

But it is even more important to clarify that the administration of dietary fiber should always be accompanied by an abundant amount of water to avoid constipation problems.
We consider it essential to recommend that the consumption of Active Tránsito Intestinal sachets be dissolved in 200-300 ml of water and add another liter and a half of water distributed throughout the day.

Protecting the integrity of the intestinal mucosa

L-Glutamine

L-Glutamine, another component of which we can find 1300 mg in each sachet of Active Intestinal Transit, is a very important cementer of the intestinal walls.

L-Glutamine maintains the intestinal barrier in good condition, as well as repairs it when it has been altered and has lost its functionality

In addition to playing a crucial role in nutrient absorption, the intestinal mucosa provides an important barrier against toxins and bacteria in the intestinal lumen.
Alteration of its function would be of vital importance in the pathogenesis of numerous gastrointestinal diseases such as inflammatory bowel disease, irritable bowel syndrome, celiac disease and infectious enterocolitis.
Specialized junction complexes called tight junctions provide the intestinal epithelial barrier function. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369670/

To better understand the mechanism of protection of the intestinal mucosa induced by glutamine, this would imply an increase in the rate of protein synthesis and a decrease in proteolysis.
In addition to the above, glutamine is an important source of energy for the proliferation and differentiation of intestinal epithelial cells. https://pubmed.ncbi.nlm.nih.gov/12579515/

More antioxidant and non-inflammatory effects

Turmeric

The 300 mg of turmeric that we will find in each sachet of Active Tránsito Intestinal provide such powerful antioxidant and anti-inflammatory capabilities, which have rarely been seen in a food supplement.

Turmeric, as an antioxidant and anti-inflammatory

The anti-inflammatory effect of curcuminoids is likely mediated by their ability to inhibit cyclooxygenase-2 (COX-2), lipoxygenase (LOX), and inducible nitric oxide synthase (iNOS).
We saw a similar effect above when we referred to dandelion, so we consider it to be a synergistic effect.

With respect to antioxidant activity, L-Glutamine would induce a greater production of glutathione in the intestinal lumen, which would increase the inhibitory power of free radicals.

More components that add up to the benefits

Magnesium

To conclude, we have three no less important components, active magnesium that would regulate and stimulate the peristaltic activity of the intestine without neglecting that the salts of this mineral have proven laxative effects.

Magnesium is used as an osmotic laxative.
They draw water from the tissues into the intestine and increase peristalsis

Regarding the cocoa content, which is 750 mg per sachet, we would like to point out that we have added it as a flavoring, but in addition, its anti-inflammatory and antioxidant actions that are given by the flavonoids are well known.
Cocoa extract would express a reduction in RNA of several macrophage-mediated pro-inflammatory agents.
Chemotactic monocyte protein 1 and tumor necrosis factor α (TNFα), interleukin (IL) 1α, and IL-6 would decrease significantly depending on the dose of cocoa extract used.
Also, because the production of approximately 90-95% of serotonin comes from the intestinal lumen and added to the fact that during inflammation, the breakdown of tryptophan leads to insufficient serotonin biosynthesis, which can increase the development of mood disorders, the addition of cocoa would induce an increase in the amount of the neurotransmitter in question. https://www.frontiersin.org/articles/10.3389/fphar.2013.00154/full?source=post_page—————————

As a corollary

Ending this article, we would like to point out that it would be almost impossible to cite each of the papers that talk about the qualities of the components of Active Intestinal Transit, so we will leave it to the reader to investigate the beneficial effects on health that they will find from each of them.

Active Intestinal Transit, food supplement based on plants, fibers, magnesium, glutamine and cocoa

We hope that this meeting has been as rewarding for you as it was for us.
We continue in the search for proven scientific information, in the continuous improvement of our products and in providing you with the best quality in everything.
See you in the next installment.
See you soon!