Benefits of telomerase activation in cardiovascular pathology

Today we talk about cardiovascular pathology and how appropriate intervention can drastically improve it.
Specifically, we will explore the potential benefits of telomerase activation, specifically in relation to the TA-65 supplement, in the context of cardiovascular pathology.

A brief review

It is known that cardiovascular pathology is one of the main causes of morbidity and mortality worldwide.
In past articles we have addressed this issue, how to prevent and improve it through the use of supplements and natural substances.
Next, we will make a brief introduction for a better understanding of the subject.

As we age, our telomeres shorten due to cell division and oxidative stress. This decrease in telomere length has been linked to cellular aging and various diseases, including cardiovascular pathology.
In addition, immune aging has been shown to correlate with higher mortality in different age groups.
DOI: 10.1016/j.exger.2007.05.001

The study aimed to evaluate the effects of TA-65, an oral telomerase activator, on the aging of immune cells and inflammation in patients over 65 years of age who had suffered an acute myocardial infarction.
The TACTIC trial was a single-center, randomized, double-blind, parallel-group, placebo-controlled, Phase 2A pilot study involving 90 participants diagnosed with coronary heart disease and myocardial infarction in the previous 6 months.

The primary outcome measure was the proportion of CD8+ T cells that were terminally differentiated effector memory cells (CD8+ TEMRA) after 12 months.
Secondary outcomes included levels of high-sensitivity C-reactive protein (hsCRP).
The results showed that there were no significant differences in the proportion of CD8+ TEMRA between the treatment groups after 12 months.

However, the TA-65 group exhibited a significant increase in total lymphocyte count, including CD3+, CD4+, and CD8+ T cells, B cells, and natural killer cells.
In addition, hsCRP levels were significantly lower in the TA-65 group compared to the placebo group.
Patients in the TA-65 group also experienced fewer adverse events.
The study concluded that TA-65 did not affect CD8+ TEMRA but increased several lymphocyte subsets and reduced inflammation in elderly patients with MI after 12 months of treatment.
Here you can read the paper:

DOI: 10.1007/s11357-023-00794-6

Telomerase and Telomeres: An Overview

Telomerase is an enzyme that can extend the length of telomeres and counteract their shortening during DNA replication.
Although telomerase activity is low in most somatic cells, it is especially active in germ cells and certain types of cancer cells.
Telomerase activation could have therapeutic implications for addressing cellular aging and associated diseases.

Mitochondrial DNA damage and telomere shortening may have commonalities and have been linked to cardiovascular disease in some studies. https://doi.org/10.1093/nar/gkm893

Secondary prevention in patients who have undergone revascularization after myocardial infarction aims to reduce their residual risk, mainly by targeting hypercholesterolemia and platelet aggregation.
Recently, inflammation has been added as a determinant of residual risk, which is measured by the highly sensitive C-reactive protein.
DOI: 10.1056/NEJMoa1707914

TA-65: A Telomerase Activation Supplement

Dr. Spyridopoulos, professor of cardiology and cardiovascular gerontology at Newcastle University, was the principal investigator of the study.
Spyridopoulos has specialized in treating heart attack survivors for more than 30 years and believes that heart attack is revolutionary, opening up treatment methods that were not possible before.

This study also showed that the cohort that took TA-65 had 30% fewer adverse events during the more than two years that the group was under observation, clearly showing the safety and benefits of using TA-65 for an extended period of time.

TA-65 is a dietary supplement that has gained attention for its ability to activate telomerase and preserve telomere length.
TA-65 has been shown to increase the activity of the enzyme in human cells in vitro and in animal studies.
However, it is important to note that human clinical studies are limited and more research is required to determine their effects on cardiovascular health.

Although, as mentioned above, specific evidence on the effects of TA-65 on cardiovascular pathology is limited, some preliminary studies suggest possible benefits.
A study in mice with coronary artery disease showed that TA-65 reduced inflammation and oxidative stress in endothelial cells, improving vascular function.
TA-65’s mechanism of action involves the activation of mitochondrial telomerase, which can improve mitochondrial function and overall cellular health.
This could potentially rejuvenate immune cells and reduce inflammation.

It is important to note that TA-65 is a dietary supplement and these should not replace conventional medical practices and it is important to consult a healthcare professional before starting any new supplement.

Conclusion

Telomerase activation and telomere length preservation are promising areas of research in the field of cardiovascular pathology.
Although studies on TA-65 and its impact on cardiovascular health are limited, there are indications of potential benefits in terms of improving endothelial function and reducing inflammation and oxidative stress.

Studies showed that TA-65 reduced immune aging and inflammation after a myocardial infarction.
The pilot trial conducted evaluated the use of TA-65 to reduce the aging of immune cells in patients after a myocardial infarction.

Remember that it is essential to adopt a comprehensive approach to cardiovascular health care, which includes healthy lifestyle habits, such as a balanced diet, regular exercise and control of risk factors.
It is always advisable to consult a healthcare professional before considering any supplement or therapeutic intervention.

As always, at Salengei we are constantly looking for supplements, interventions and good lifestyle habits that improve health and cancel or delay the onset of preventable diseases.