Active Revive Celular, the anti-aging revolution

From Salengei, we are very excited to present a product from the Active Supplements line that we have recently launched and of which we are extremely proud.
It’s Active Revive Cellular, which is everything we’ve ever wanted to put at your fingertips in a single supplement.

Introduction to Aging

It is well known that the fight against the negative effects of ageing is increasingly becoming the focus of attention of scientists and researchers.
Not only for the simple fact of extending life expectancy, but also to counteract diseases associated with aging.

There are several pages that we have dedicated to this topic in our blog and we will continue to do so, because each scientific advance that adds new expectations, not only encourages us, but challenges us to try it in order to offer it through our products.

If you want to remember some of the most well-known theories of aging, click here to redirect you to an article where we commented on it.

Lifestyle changes can improve people’s health, but they alone are not enough to prevent diseases of old age.
Among the strategies that have been used are repurposing existing drugs for geroprotection, which provide an additional weapon in the prevention of age-related deterioration, but as they are drugs, adverse effects always appear.

What affects the most

In one of the online meetings we had with our network of doctors, we commented that there are two phenomena that apparently share the most well-known theories of aging; immunoaging and inflammaging.

Human aging can be explained by the emerging concept of a combination of topics that are currently very much on the rise, which are the combination of immune senescence, inflammation, and aging.
The inflammaging theory posits that aging, whether physiological or pathological, can be driven by cytokines and pro-inflammatory substances produced by the innate immune system.
The concept of inflammation is based on a theory of programmed antagonistic pleitropy during evolution. https://doi.org/10.2492/inflammregen.29.249

When we analyze immunaging, we would be focusing on the progressive filling of the immune system by activated lymphocytes, macrophages and dendritic cells in response to chronic diseases and subtle stress on an ongoing basis. This stress can be pathological or due to physiological antigens/toxins.
Thus, the condition of inflammation provides a mild and continuous antigenic action that leads to a pro-inflammatory condition associated with the progressive stimulation/exhaustion of the immune system and other systems of the body.

In general, immunosenescence can be taken as proof that the beneficial effects of the immune system, dedicated to the neutralization of dangerous and harmful agents that appear early in life, and that serve to improve the development and maturation tending to the prosperity of future generations and species in adulthood, they become harmful late in life.
This is happening within a framework that would cover a period largely unforeseen by evolution. https://doi.org/10.1111/j.1749-6632.2000.tb06651.x

The most studied patterns or seals about aging

Human aging consists of an evolved mechanism of multiple hallmarks or patterns.
This multi-layered view sheds light on the overall deleterious process.
These stamps are cited below:

1. Genetic instability: DNA deterioration impacts cellular and mitochondrial functioning.
   There is evidence that upregulating the mechanisms of repair of the same prolongs survival.
2. Telomere shortening: aging causes the ends of chromosomes to shorten, marking an older cell behavior, with fewer divisions and regeneration of tissues, and consequently more diseases.
3. Epigenetic alterations: the assembly instructions that come in our genome do not determine our health completely.
   There are many mechanisms that allow us to interpret our guidelines in a better or worse way, facilitating or hindering the appearance of diseases to which we were predisposed.
4. Loss of proteostasis: the proteins in our body are in a constant cycle of creation, deterioration and elimination.
   The loss of this balance produces an accumulation of protein waste in numerous organs, damaging their function.
5. Dysregulation of nutrient sensitivity: over the years our body reacts less well to nutrients, producing resistance to insulin and other hormonal axes.
   Calorie restriction or its simulation with drugs has been shown to increase longevity; Hormone replacement also combats the effects of aging on target tissues.
6. Mitochondrial dysfunction: mitochondria are the powerhouses from which we obtain energy through nutrients.
   Its dysfunction uncontrols oxidative stress and accelerates aging.
7. Cellular senescence: when apoptosis is altered, tissues accumulate aged and poorly functional cells, and in the long term it is the tissue/organ itself that stops functioning properly.
8. Stem cell depletion: The reparative mechanisms of stem cells ensure greater survival and ability to reproduce.
   The exhaustion of this capacity means that we are not able to regenerate properly after a certain age.
9. Alteration of intercellular communication: the alteration of hormonal systems, inflammation and the loss of blood-stimulating factors cause aging to go beyond a specific cell and become contagious.

How can we intervene in the different hallmarks of aging?

Cells have different sets of molecules to perform a number of physiological functions. Nucleic acids have stored and transported information throughout evolution, while proteins have been credited with performing most cellular functions.

These attributes are achieved by a highly coordinated protein quality control (PQC) system comprising chaperones to fold proteins into a suitable three-dimensional structure, a ubiquitin-proteasome system for selective protein degradation, and autophagy for mass removal of cellular debris.

Many disturbances can lead to the weakening of the protective cellular machinery, leading to the deployment and aggregation of cellular proteins and the appearance of numerous pathological conditions.
However, modulation of the expression and functional efficiency of molecular chaperones, E3 ubiquitin ligases and autophagic proteins can decrease the cellular proteotoxic load and mitigate several pathological effects.

Natural medicine and small molecule-based therapies have been well documented for their effectiveness in modulating these pathways and restoring lost proteostasis within cells to fight disease. https://doi.org/10.3389/fgene.2021.693071

The Achievement: Active Revive Cellular

By documenting all the processes detailed above, we have tried to come together in a product that adds active ingredients that act directly on all the layers associated with aging.
Below, we leave a list of the main components of Active Revive Cellular.

• Fisetin.
  It is the flavonoid present in foods such as strawberries and apples with the potential ability to reduce cellular senescence.
  In a study on the longevity effects of flavonoids, fisetin was the most potent senolytic.
  Other beneficial effects: anti-inflammatory, neuroprotective, anticancer and antidiabetic.
• Green tea. It is rich in polyphenols, among which catechins stand out and the most abundant is epigallocatechingallate (EGCG), with high antioxidant power.
  It also has an anti-photoaging effect, resistance to stress, is neuroprotective and activates autophagy through the mTOR pathway.

Warnings: Doses greater than 800 mg EGCG/day, taken as a supplement may induce a statistically significant increase in serum transaminases.

• Quercetin.
  It is the flavonoid found in a wide variety of foods such as apples, onions, berries, broccoli and spinach.
  To get an idea, 100 grams of raw red onion per day is equivalent to 78 mg of quercetin.
  In addition, it has properties with an anti-aging effect at the cellular level: it improves cell function, reduces inflammation, reduces oxidative stress and improves mitochondrial function.
• Tetrahydrocurcumin (THC).
  Curcumin is a polyphenol from the curcuminoid family found in the rhizomes of turmeric.
  Curcumin is involved in the inhibition of certain pro-inflammatory signaling pathways and cytokines such as TNF-α, IL-1b, IL-6, IL-8 and monocyte chemotactic protein 1 [MPC-1], transcription signal transducer activator (STAT), receptor (PPAR-γ), activating transcription factor 3 (ATF3), homologous protein C/EBP (CHOP) and the inducible inflammatory enzymes cilclooxygenase- (COX-) 2 and metalloproteinases.
  In addition, it decreases oxidative stress by increasing the activity of superoxide dismutase and decreasing the levels of malondialdehyde (MDA) and lipofuscin.
  On the other hand, it modulates the main signaling pathways that influence longevity: IIS, mTOR, PKA and FOXO. At Salengei we use Curcumin C3 REDUCT® which is a form of curcumin with a minimum of 95% tetrahydrocurcumin (THC), tetrahydrodemethoxycurcumin (THDMC) and tetrahydrobisdemethoxycurcumin (THBDMC).
  It has a better absorption profile in the gut than the original curcuminoids and better stability at physiological pH.
• Reishi.
  It is a medicinal mushroom used by traditional Chinese and Japanese medicine.
  It has been shown to increase longevity by inducing autophagy and resistance to stress.
  Active Revive Celular has been formulated with dry extract of Reishi sporophores, the part of this medicinal mushroom with the highest concentration of bioactive compounds.
  The polysaccharides and triterpenes present in Reishi sporophores have been shown to possess immunomodulatory, antioxidant, anti-inflammatory and anti-tumor properties.

• Trans resveratrol.
  Resveratrol is a polyphenol present in foods such as grapes and has been the subject of numerous studies due to its potential beneficial effects on health, including its anti-aging effect. Anti-aging properties of resveratrol: antioxidant, activation of sirtuins in addition to inhibiting the mTOR pathway, which produces activation of autophagy.
• PQQ, or pyrroloquinoline quinone. It is a cofactor and natural compound found in some foods, such as tofu, parsley, and green tea.
  It has antioxidant and anti-inflammatory properties and has been researched for its potential health effects, including improving cognitive function, reducing the risk of cardiovascular disease, and protecting the liver.
  In college-age human subjects, Harris et al.
  reported that it reduced C-reactive protein, interleukin-6 levels, and plasma malonaldehyde levels.
  Other studies have shown that daily supplementation with 20 mg of PQQ optimizes mitochondrial biogenesis.
  In particular, cognitive function and memory also improve in human subjects, following PQQ supplementation
• Berberine. It is a natural compound found in some plants, such as barberry root (Berberis vulgaris).
  It has been researched for its potential health effects, including lowering blood sugar, lowering blood pressure, triglycerides, and cholesterol.
• Astaxanthin. It is a natural pigment found in certain algae, plants, and some aquatic animals, such as salmon and shrimp.
  It is known for its antioxidant and anti-inflammatory properties and has been researched for its potential health effects, including reducing oxidative stress, improving cognitive function, and protecting the skin from sun damage.

Conclusion

There are many mechanisms involved in aging.
And there are many layers or seals that act in a related way so that it can be carried out.

At Salengei we believe that, by intervening correctly in some decisive steps of this process, we will be able to slow down aging and prevent the diseases associated with it.

Imagine for a moment that you could take a supplement that prevented age-related deterioration and could keep you healthy.
Different scientific studies and ourselves have turned the subject around trying to find something that has these effects.
This is how Active Revive Celular was born.